{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:59:38Z","timestamp":1772117978930,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,3]],"date-time":"2024-03-03T00:00:00Z","timestamp":1709424000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Craniopharyngiomas are low\u2010grade malignancies (WHO I) in the sellar region. Most cases of childhood\u2010onset craniopharyngioma are adamantinomatous craniopharyngioma, and neurosurgery is the treatment of choice. Affected patients have postoperative complications, including water and electrolyte disturbances, because these malignancies develop near the hypothalamus and pituitary gland. Determining postoperative serum sodium fluctuation patterns in these patients can reduce postoperative mortality and improve prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To measure changes in serum sodium levels in pediatric patients who underwent craniopharyngioma surgery and identify influencing factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study measured the serum sodium levels of 202 patients aged 0\u201318 years who underwent craniopharyngioma resection in Beijing Tiantan Hospital and Beijing Children's Hospital and identified predictors of severe hyponatremia and hypernatremia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age of the cohort was 8.35\u00a0\u00b1\u00a04.35 years. The prevalence of hypernatremia, hyponatremia, and their severe forms (serum Na\n                      <jats:sup>+<\/jats:sup>\n                      \u00a0&gt;\u00a0150\u00a0mmol\/L and serum Na\n                      <jats:sup>+<\/jats:sup>\n                      \u00a0&lt;\u00a0130\u00a0mmol\/L) within 14 days after surgery was 66.3%, 72.8%, 37.1%, and 40.6%, respectively. The mean postoperative serum sodium level showed a triphasic pattern, characterized by two peaks separated by a nadir. Sodium levels peaked on days 2 (143.6\u00a0\u00b1\u00a07.6\u00a0mmol\/L) and 14 (143.2\u00a0\u00b1\u00a06.7\u00a0mmol\/L) and reached their lowest on day 6 (135.5\u00a0\u00b1\u00a07.5\u00a0mmol\/L). A total of 31 (15.3%) patients met the diagnostic threshold for hyponatremia and hypernatremia of the triphase response, whereas 116 (57.4%) patients presented this pattern, regardless of met the diagnostic criteria or not. The prevalence of severe hyponatremia varied depending on preoperative endocrine hormone deficiency, tumor status (primary or recurrent), and surgical approach.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Serum sodium levels after craniopharyngioma resection in children showed a triphasic pattern in most cases. The risk of postoperative hyponatremia varied depending on preoperative endocrine hormone deficiency, tumor status (primary or recurrent), and surgical approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3430","type":"journal-article","created":{"date-parts":[[2024,3,3]],"date-time":"2024-03-03T22:19:39Z","timestamp":1709504379000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Serum sodium level fluctuations following the resection of childhood\u2010onset craniopharyngioma"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3513-3685","authenticated-orcid":false,"given":"Yuqi","family":"Miao","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Genetics and Metabolism Beijing Children's Hospital, Capital Medical University, National Center for Children's Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiyu","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurosurgery Beijing Tiantan Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojiao","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Beijing Children's Hospital, Capital Medical University, National Center for Children's Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Development Biology Institute of Genetics and Developmental Biology, Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Genetics and Metabolism Beijing Children's Hospital, Capital Medical University, National Center for Children's Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Genetics and Metabolism Beijing Children's Hospital, Capital Medical University, National Center for Children's Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaxian","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Pediatric Beijing Tiantan Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengsong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Children's Hospital, Capital Medical University, National Center for Children's Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingfeng","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Development Biology Institute of Genetics and Developmental Biology, Chinese Academy of Sciences  Beijing China"},{"name":"Beijing Key Laboratory for Genetics of Birth Defects  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Beijing Children's Hospital, Capital Medical University, National Center for Children's Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurosurgery Beijing Tiantan Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Genetics and Metabolism Beijing Children's Hospital, Capital Medical University, National Center for Children's Health  Beijing China"},{"name":"Beijing Key Laboratory for Genetics of Birth Defects  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,3]]},"reference":[{"key":"e_1_2_11_2_1","article-title":"A ten\u2010year follow\u2010up study of treatment outcome of craniopharyngiomas","volume":"148","author":"Andereggen L.","year":"2018","journal-title":"Swiss Medical Weekly: Official Journal of the Swiss Society of Infectious Diseases, the Swiss Society of Internal Medicine, the Swiss Society of Pneumology"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-005-1186-5"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4183\/aeb.2018.549"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02754.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000370065"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324115"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000368401"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.galenos.2018.2018.0182"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14334"},{"issue":"1","key":"e_1_2_11_11_1","first-page":"502","article-title":"Concurrent central diabetes insipidus and cerebral salt wasting disease in a post\u2010operative case of craniopharyngioma: A case report","volume":"21","author":"Jameel P. Z.","year":"2021","journal-title":"BMC Pediatrics [Electronic Resource]"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(86)90152-2"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet0513"},{"issue":"4","key":"e_1_2_11_14_1","first-page":"193","article-title":"Childhood craniopharyngioma. Recent advances in diagnosis, treatment and follow\u2010up","volume":"69","author":"Muller H. L.","year":"2008","journal-title":"Hormone Research"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2010.168"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0125-9"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2013-1115"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2007.20.10.1145"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2004.tb00476.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-013-2041-8"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.4531"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3171\/2015.7.PEDS15277"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.3430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T01:14:08Z","timestamp":1711415648000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.3430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/brb3.3430"],"URL":"https:\/\/doi.org\/10.1002\/brb3.3430","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.3430\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3430\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3430\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3430\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"2023-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3430"}}