{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:38:41Z","timestamp":1788907121638,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015539","name":"Australian Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015539","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Frontal and posterior\u2010cortical cognitive subtypes in Parkinson's disease (PD) present with executive\/attention and memory\/visuospatial deficits, respectively. As the posterior\u2010cortical subtype is predicted to progress rapidly toward dementia, the present study aimed to explore biological markers of this group using resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:italic>K<\/jats:italic>\n                      \u2010means cluster analysis delineated subtypes (cognitively intact, frontal, posterior\u2010cortical, and globally impaired) among 85 people with PD. A subset of PD participants (\n                      <jats:italic>N\u00a0<\/jats:italic>\n                      =\u00a042) and 20 healthy controls (HCs) underwent rs\u2010fMRI. Connectivity of bilateral hippocampi with regions of interest was compared between posterior\u2010cortical, cognitively intact, and HC participants using seed\u2010based analysis, controlling for age. Exploratory correlations were performed between areas of interest from the group analysis and a series of cognitive tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The posterior\u2010cortical subtype (\n                      <jats:italic>N\u00a0<\/jats:italic>\n                      =\u00a019) showed weaker connectivity between the left hippocampus and right anterior temporal fusiform cortex compared to the cognitively intact (\n                      <jats:italic>N\u00a0<\/jats:italic>\n                      =\u00a011) group,\n                      <jats:italic>p\u2010<\/jats:italic>\n                      false discovery rate (FDR)\u00a0=\u00a0.01, and weaker connectivity between bilateral hippocampi and most fusiform regions compared to HCs (\n                      <jats:italic>N\u00a0<\/jats:italic>\n                      =\u00a020). No differences were found between HCs and cognitively intact PD. Exploratory analyses revealed strongest associations between connectivity of the right anterior temporal fusiform cortex and left hippocampus with category fluency (\n                      <jats:italic>p\u2010<\/jats:italic>\n                      FDR\u00a0=\u00a0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Results suggest that weakened connectivity between the hippocampus and fusiform region is a unique characteristic of posterior\u2010cortical cognitive deficits in PD. Further exploration of hippocampal and fusiform functional integrity as a marker of cognitive decline in PD is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3454","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T03:08:57Z","timestamp":1710212937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hippocampal resting\u2010state connectivity is associated with posterior\u2010cortical cognitive impairment in Parkinson's disease"],"prefix":"10.1002","volume":"14","author":[{"given":"Dana","family":"Pourzinal","sequence":"first","affiliation":[{"name":"Faculty of Medicine The University of Queensland Centre for Clinical Research  Herston Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihyun","family":"Yang","sequence":"additional","affiliation":[{"name":"Faculty of Medicine The University of Queensland Centre for Clinical Research  Herston Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie L.","family":"McMahon","sequence":"additional","affiliation":[{"name":"School of Clinical Sciences, Faculty of Health Queensland University of Technology  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Copland","sequence":"additional","affiliation":[{"name":"Queensland Aphasia Research Centre, School of Health and Rehabilitation Sciences The University of Queensland  Brisbane Australia"},{"name":"Surgical Treatment and Rehabilitation Service (STARS) Education and Research Alliance The University of Queensland and Metro North Health  Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leander","family":"Mitchell","sequence":"additional","affiliation":[{"name":"School of Psychology The University of Queensland  St Lucia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"O'Sullivan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine The University of Queensland Centre for Clinical Research  Herston Australia"},{"name":"Department of Neurology Royal Brisbane &amp; Women's Hospital  Herston Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard J.","family":"Byrne","sequence":"additional","affiliation":[{"name":"Faculty of Medicine The University of Queensland Centre for Clinical Research  Herston Australia"},{"name":"Mental Health Service Royal Brisbane &amp; Women's Hospital  Herston Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0164-3337","authenticated-orcid":false,"given":"Nadeeka N.","family":"Dissanayaka","sequence":"additional","affiliation":[{"name":"Faculty of Medicine The University of Queensland Centre for Clinical Research  Herston Australia"},{"name":"School of Psychology The University of Queensland  St Lucia Australia"},{"name":"Department of Neurology Royal Brisbane &amp; Women's Hospital  Herston Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010021\u201000280\u20103"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188196"},{"key":"e_1_2_11_4_1","article-title":"Hopkin's verbal learning test\u2010revised\/brief visuospatial memory test\u2010revised: Professional manual supplement","author":"Benedict R. H. B.","year":"2007","journal-title":"Psychological Assessment Resources"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467\u2010842X.2001.tb00294.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000503"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2014.01.009"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh088"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2015.00471"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/13854046.2011.564209"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23101"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep26148"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.573"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617704102191"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.10091"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.6.745"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21198"},{"key":"e_1_2_11_18_1","volume-title":"Stroop colour and word test: A manual for clinical and experimental uses","author":"Golden C. J.","year":"2002"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14094"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu036"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00247"},{"key":"e_1_2_11_22_1","volume-title":"Boston naming test","author":"Kaplan E.","year":"1983"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341998"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.09.045"},{"key":"e_1_2_11_25_1","volume-title":"Neuropsychological assessment","author":"Lezak M. D.","year":"2012"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24893"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv211"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741\u20106612.2010.00487.x"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2009.21219"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532\u20105415.2005.53221.x"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-803452-1.00004-7"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro\u20102018\u20100117"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201070410\u20106"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101186"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531\u20108249(200004)47:4<470::AID\u2010ANA10>3.0.CO;2\u2010M"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000466"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24863"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010020\u201009977\u2010z"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.64.5.588"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.07.047"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23\u201003\u201000994.2003"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23429"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.07.017"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.05.005"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102013\u2010305277"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682\u2010022\u201000698\u20107"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161935"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429\u2010014\u20100907\u20105"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1300\/J018v05n01_09"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.3454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T01:13:57Z","timestamp":1711415637000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.3454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/brb3.3454"],"URL":"https:\/\/doi.org\/10.1002\/brb3.3454","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.3454\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3454\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3454\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3454\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3454\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3454\/v1\/review2","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"2023-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3454"}}