{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:05:44Z","timestamp":1753862744473,"version":"3.41.2"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601139"],"award-info":[{"award-number":["81601139"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite numerous investigations into the relationship between physical activities (PA) and epilepsy, the causal effects remain contentious. Thus, we conducted a two\u2010sample Mendelian randomization (MR) study to assess the potential causality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Single\u2010nucleotide polymorphisms (SNPs) predisposed to self\u2010reported moderate and vigorous physical activities (MPA and VPA) and overall acceleration average (OAA) calculated through wrist\u2010worn accelerometers were selected as exposure instrumental variables. Five subtypes of epilepsy, including all epilepsy, focal epilepsy and generalized epilepsy (with or without each other), focal epilepsy\u2010strict definition and generalized epilepsy\u2010strict definition (without overlap), were chosen as the outcomes. The MR study utilized the inverse\u2010variance weighted (IVW) method as the primary analytical tool, supplemented by MR\u2010Egger, simple mode, weighted mode, and weighted median methods. Cochran's Q and MR\u2010Egger intercept tests were employed to assess heterogeneity and pleiotropy, while MR pleiotropy residual sum and outlier and leave\u2010one\u2010out analyses were conducted to identify potential SNP outliers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study indicated that OAA was genetically linked to a decreased risk of both focal epilepsy (OR\u00a0=\u00a00.812, 95% CI: 0.687\u20130.960, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.015, IVW) and focal epilepsy\u2010strict definition (OR\u00a0=\u00a00.732, 95% CI: 0.596\u20130.900, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.003, IVW; OR\u00a0=\u00a00.749, 95% CI: 0.573\u22120.979, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.035, Weighted median). Genetically predicted MPA and VPA did not exhibit a causal association with all epilepsy or its subtypes (<jats:italic>p<\/jats:italic>&gt;.05). No evidence of heterogeneity, pleiotropy, or SNP outlier was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggested that PA with accelerometer monitoring may potentially reduce the risk of focal epilepsy, while there is no evidence supporting causal association between self\u2010reported MPA or VPA and either focal or generalized epilepsy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.3463","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T10:51:54Z","timestamp":1709808714000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic causal association between physical activities and epilepsy: A Mendelian randomization study"],"prefix":"10.1002","volume":"14","author":[{"given":"Peihong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology, Xiangya Hospital Central South University  Changsha Hunan 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Disorders, Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9250-151X","authenticated-orcid":false,"given":"Luo","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073815574334"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31821ece12"},{"volume-title":"Epilepsy: A public health imperative: 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