{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T04:23:29Z","timestamp":1772511809251,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T00:00:00Z","timestamp":1714262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>The ANNEXA\u20104 trial measured hemostatic efficacy of andexanet alfa in patients with major bleeding taking factor Xa inhibitors. A proportion of this was traumatic and nontraumatic intracranial bleeding. Different measurements were applied in the trial including volumetrics to assess for intracranial bleeding depending on the compartment involved. We aimed to determine the most reliable way to measure intracranial hemorrhage (ICrH) volume by comparing individual brain compartment and total ICrH volume.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty patients were randomly selected from the ANNEXA\u20104 database to assess measurement of ICrH volume by compartment and in total. Total and compartmental hemorrhage volumes were measured by five readers using Quantomo software. Each reader measured baseline hemorrhage volumes twice separated by 1 week. Twenty\u2010eight different ANNEXA\u20104 subjects were also randomly selected to assess intra\u2010rater reliability of total ICrH volume measurement change at baseline and 12\u2010h follow up, performed by three readers twice to assess hemostatic efficacy categories used in ANNEXA\u20104.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compartmental minimal detectable change percentages (MDC%) ranged between 9.72 and 224.13, with the greatest measurement error occurring in patients with a subdural hemorrhage. Total ICrH volume measurements had the lowest MDC%, which ranged between 6.57 and 33.52 depending on the reader.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Measurement of total ICrH volumes is more accurate than volume by compartment with less measurement error. Determination of hemostatic efficacy was consistent across readers, and within the same reader, as well as when compared to consensus read. Volumetric analysis of intracranial hemostatic efficacy is feasible and reliable when using total ICrH volumes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3481","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T02:49:32Z","timestamp":1714358972000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Total intracranial hemorrhage volume measurement summating all compartments best in traumatic and nontraumatic intracranial bleeding"],"prefix":"10.1002","volume":"14","author":[{"given":"MacKenzie","family":"Horn","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences University of Calgary Calgary Canada"},{"name":"Department of Radiology University of Calgary Calgary 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McMaster University Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Ladenvall","sequence":"additional","affiliation":[{"name":"Biopharmaceuticals R&amp;D, AstraZeneca M\u00f6lndal Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Crowther","sequence":"additional","affiliation":[{"name":"Department of Medicine McMaster University Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Beyer\u2010Westendorf","sequence":"additional","affiliation":[{"name":"University Hospital Carl Gustav Carus Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashkan","family":"Shoamanesh","sequence":"additional","affiliation":[{"name":"Department of Medicine McMaster University Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew M.","family":"Demchuk","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences University of Calgary Calgary Canada"},{"name":"Department of Radiology University of Calgary Calgary Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2849-5386","authenticated-orcid":false,"given":"Abdulaziz S.","family":"Al Sultan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Neurology Royal Columbian Hospital New Westminster Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the ANNEXa\u20104 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