{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T22:08:13Z","timestamp":1769119693697,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,5,30]],"date-time":"2015-05-30T00:00:00Z","timestamp":1432944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cervical artery dissection (Ce<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) patients with or without stroke are frequently treated with either antiplatelet agents or vitamin K antagonists (<jats:styled-content style=\"fixed-case\">VKA<\/jats:styled-content>s), but few data are reported on the use of nonvitamin K oral anticoagulants (<jats:styled-content style=\"fixed-case\">NOAC<\/jats:styled-content>s).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between November 2011 and January 2014, we recorded data from patients with a stroke due to vertebral (<jats:styled-content style=\"fixed-case\">VAD<\/jats:styled-content>) or internal carotid artery dissection (<jats:styled-content style=\"fixed-case\">ICAD<\/jats:styled-content>). Patients using oral anticoagulants were included in the study and were divided into two treatment groups: patients using <jats:styled-content style=\"fixed-case\">NOAC<\/jats:styled-content>s and those using <jats:styled-content style=\"fixed-case\">VKA<\/jats:styled-content>s. Excellent outcome was defined on modified Rankin Scale (<jats:styled-content style=\"fixed-case\">mRS<\/jats:styled-content>) \u22641 at 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 68 stroke patients (67% male; median age 45 [39\u201353]), six (8.8%; two with <jats:styled-content style=\"fixed-case\">VAD<\/jats:styled-content> and four with <jats:styled-content style=\"fixed-case\">ICAD<\/jats:styled-content>) were treated with <jats:styled-content style=\"fixed-case\">NOAC<\/jats:styled-content>s: three with direct thrombin inhibitor dabigatran and three with direct factor Xa inhibitor rivaroxaban. National Institutes of Health Stroke Scale score at baseline was 4 (3\u20137) in the <jats:styled-content style=\"fixed-case\">NOAC<\/jats:styled-content> versus 2 (1\u20137) in the <jats:styled-content style=\"fixed-case\">VKA<\/jats:styled-content> groups. Complete recanalization at 6\u00a0months was seen in most patients in the <jats:styled-content style=\"fixed-case\">NOAC<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a05; 83%) and <jats:styled-content style=\"fixed-case\">VKA<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a034; 55%) groups. All the patients using <jats:styled-content style=\"fixed-case\">NOAC<\/jats:styled-content>s had <jats:styled-content style=\"fixed-case\">mRS<\/jats:styled-content> \u22641 at 6\u00a0months and none had an intracerebral hemorrhage (<jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>). In the <jats:styled-content style=\"fixed-case\">VKA<\/jats:styled-content> group most patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a048; 77%) had <jats:styled-content style=\"fixed-case\">mRS<\/jats:styled-content> \u22641, one patient (1.7%) had an <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> and one died.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this small, consecutive single\u2010center patient sample treating ischemic stroke patients with Ce<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">NOAC<\/jats:styled-content>s did not bring up safety concerns and resulted in similar, good outcomes compared to patients using <jats:styled-content style=\"fixed-case\">VKA<\/jats:styled-content>s.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.349","type":"journal-article","created":{"date-parts":[[2015,5,31]],"date-time":"2015-05-31T04:28:50Z","timestamp":1433046530000},"source":"Crossref","is-referenced-by-count":24,"title":["Helsinki experience on nonvitamin K oral anticoagulants for treating cervical artery dissection"],"prefix":"10.1002","volume":"5","author":[{"given":"Satu","family":"Mustanoja","sequence":"first","affiliation":[{"name":"Department of Neurology Helsinki University Central Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiina M.","family":"Metso","sequence":"additional","affiliation":[{"name":"Department of Neurology Helsinki University Central Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Putaala","sequence":"additional","affiliation":[{"name":"Department of Neurology Helsinki University Central Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noora","family":"Heikkinen","sequence":"additional","affiliation":[{"name":"Department of Neurology Helsinki University Central Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Haapaniemi","sequence":"additional","affiliation":[{"name":"Department of Neurology Helsinki University Central Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oili","family":"Salonen","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Helsinki University Central Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turgut","family":"Tatlisumak","sequence":"additional","affiliation":[{"name":"Department of Neurology Helsinki University Central Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000109766.27393.52"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000366265"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905561"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000056"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.489666"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.006167"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107039"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2012.00954.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6485-7"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.10.035"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009638"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.07.104"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072697"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12228"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbrb3.349","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.349","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.349","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T15:38:15Z","timestamp":1696606695000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,30]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1002\/brb3.349"],"URL":"https:\/\/doi.org\/10.1002\/brb3.349","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,30]]},"article-number":"e00349"}}