{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:05:45Z","timestamp":1753862745867,"version":"3.41.2"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T00:00:00Z","timestamp":1713484800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Generalized joint hypermobility (GJH) can be the result of several hereditary connective tissue disorders, especially Ehlers\u2013Danlos syndrome. Cerebrovascular manifestations are among the most common complications in this disorder, and understanding their extent can help better diagnosis and prevention of hazardous events. We investigated visual evoked potential (VEP) changes in patients with GJH and compared them with healthy individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our case\u2013control study included 90 patients who fulfilled the Beighton score (B score) for joint hypermobility and other 90 healthy participants. All of them went under VEP study, and the amplitude and latency of the evoked potential (P100) were compared to each other.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Case group had significantly higher B score (7.18\u00a0\u00b1\u00a00.967 vs. 1.18\u00a0\u00b1\u00a00.712), P100 latency (110.23\u00a0\u00b1\u00a06.64\u00a0ms vs. 100.18\u00a0\u00b1\u00a04.273\u00a0ms), and amplitude (6.54\u00a0\u00b1\u00a01.26\u00a0mv vs. 6.50\u00a0\u00b1\u00a01.29\u00a0mv) compared with the Control group, but the difference was only significant regarding B score, and P100 latency (<jats:italic>p<\/jats:italic>\u2010value &lt;.0001). Moreover, both latency and amplitude of P100 had significantly positive correlations with the B score in the Case group (<jats:italic>p<\/jats:italic>\u2010value &lt;.0001), but such correlations were not found in the Control group (<jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a0.059).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study could reveal VEP changes, especially significant P100 latency in GJH patients without previous neurologic or musculoskeletal disorders. Whether these changes are due to GJH itself or are predictive of inevitable neurologic disease or visual pathway involvement, particularly Multiple Sclerosis needs further investigation with longer follow\u2010up periods.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.3493","type":"journal-article","created":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T06:12:55Z","timestamp":1713593575000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Visual evoked potential in generalized joint hypermobility: A case\u2013control study"],"prefix":"10.1002","volume":"14","author":[{"given":"Leila Sadat Mohamadi","family":"Jahromi","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Shiraz Medical School Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0824-1901","authenticated-orcid":false,"given":"Amin","family":"Sayyadi","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Shiraz Medical School Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Askarian","sequence":"additional","affiliation":[{"name":"Shiraz Medical School Shiraz University of Medical Sciences (SUMS)  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Dabbaghmanesh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Shiraz Medical School Shiraz University of Medical Sciences (SUMS)  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharareh","family":"Roshanzamir","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Shiraz Medical School Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,19]]},"reference":[{"volume-title":"Visual evoked potential","year":"2023","author":"Baiano C.","key":"e_1_2_12_2_1"},{"issue":"1","key":"e_1_2_12_3_1","first-page":"43","article-title":"Clinical management of benign joint hypermobility syndrome: A case series","volume":"64","author":"Boudreau P. A.","year":"2020","journal-title":"The Journal of the Canadian Chiropractic Association"},{"issue":"4","key":"e_1_2_12_4_1","first-page":"190","article-title":"Neurological manifestations of Ehlers\u2013Danlos syndrome (s): A review","volume":"13","author":"Castori M.","year":"2014","journal-title":"Iranian Journal of Neurology"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1444\u20100938.2012.00706.x"},{"volume-title":"Physical medicine and rehabilitation: Principles and practice","year":"2005","author":"DeLisa J. A.","key":"e_1_2_12_6_1"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102019\u2010031365"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31549"},{"issue":"2","key":"e_1_2_12_9_1","first-page":"116","article-title":"Coexistence of Ehlers\u2013Danlos syndrome and multiple sclerosis","volume":"14","author":"Kose Ozlece H.","year":"2015","journal-title":"Iranian Journal of Neurology"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1072785"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296\u2010021\u201004832\u20104"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028\u20103886.16938"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2021.12.005"},{"issue":"3","key":"e_1_2_12_14_1","first-page":"269","article-title":"Assessing construct validity of the Beighton score as a measure of generalized joint hypermobility in varsity athletes","volume":"67","author":"Parks A.","year":"2023","journal-title":"Journal of the Canadian Chiropractic Association"},{"issue":"11","key":"e_1_2_12_15_1","first-page":"909","article-title":"[Visual evoked potential parameters in multiple sclerosis in developmental age]","volume":"66","author":"Steczkowska M.","year":"2009","journal-title":"Przeglad Lekarski"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59122160"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458507083187"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12837"},{"issue":"2","key":"e_1_2_12_19_1","first-page":"382","article-title":"Visual pathways involvement in clinically isolated syndrome in children","volume":"8","author":"Voitenkov V.","year":"2015","journal-title":"International Journal of Ophthalmology"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102415\u201012\u201047"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.3493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:17:32Z","timestamp":1715609852000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.3493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/brb3.3493"],"URL":"https:\/\/doi.org\/10.1002\/brb3.3493","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"type":"print","value":"2162-3279"},{"type":"electronic","value":"2162-3279"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"2023-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3493"}}