{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:19:07Z","timestamp":1785381547374,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The internal representation of verticality could be disturbed when a lesion in the central nervous system (CNS) affects the centers where information from the vestibular, visual, and\/or somatosensory systems, increasing the risk of falling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim was to evaluate the vestibular and somatosensory contribution to the verticality pattern in patients with stroke and other neurological disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature search was performed in PubMed, Scopus, Web of Science, and CINAHL databases. Cross\u2010sectional, case\u2013control, and cohort studies comparing body verticality in patients with stroke or CNS diseases (CNSD) versus healthy controls were selected. Subjective postural vertical (SPV) in roll and pitch planes was used as the primary variable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten studies reporting data from 390 subjects were included. The overall effect for CNSD patients showed a misperception of body verticality in roll (standardized mean difference [SMD]\u00a0=\u00a01.05; 95% confidence interval [CI]\u00a0.84\u20131.25) and pitch planes (SMD\u00a0=\u00a01.03; 95% CI\u00a0.51\u20131.55). In subgroup analyses, a high effect was observed in the perception of SPV both in roll and pitch planes in stroke (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.002) and other CNSD (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest a potential misperception of SPV in patients with stroke and other neurological disturbances. Patients with CNSD could present an alteration of vestibular and somatosensory contribution to verticality construction, particularly stroke patients with pusher syndrome (PS), followed by those with PS combined with hemineglect.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.3496","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T02:44:48Z","timestamp":1714531488000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Misperception of body verticality in neurological disorders: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8430-5500","authenticated-orcid":false,"given":"Esteban","family":"Obrero\u2010Gait\u00e1n","sequence":"first","affiliation":[{"name":"Department of Health Sciences University of Jaen  Jaen Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Fuentes\u2010N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University of Jaen  Jaen Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Del","family":"Moral\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University of Jaen  Jaen Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3589-8423","authenticated-orcid":false,"given":"Mar\u00eda del Carmen","family":"L\u00f3pez\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University of Jaen  Jaen Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6814-1091","authenticated-orcid":false,"given":"Daniel","family":"Rodr\u00edguez\u2010Almagro","sequence":"additional","affiliation":[{"name":"Department of Nursing, Physiotherapy and Medicine University of Almeria  Almeria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Lomas\u2010Vega","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University of Jaen  Jaen Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.1999.tb09199.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.5152\/iao.2017.4056"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7454.1490"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150754"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucli.2013.02.001"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2020.135055"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/10749357.2015.1135591"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u2010444\u201063437\u20105.00004\u20102"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883\u2010019\u20101442\u2010z"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1525\/ae.2004.31.4.475"},{"key":"e_1_2_10_12_1","volume-title":"The handbook of research synthesis and meta\u2010analysis","author":"Cooper H.","year":"2009"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u2010444\u201063916\u20105.00003\u20103"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197\u20102456(86)90046\u20102"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00172"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006\u2010341X.2000.00455.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rehab.2022.101700"},{"key":"e_1_2_10_18_1","first-page":"700","article-title":"Interpreting estimates of treatment effects: Implications for managed care","volume":"33","author":"Faraone S. 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