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The functional magnetic resonance imaging technique can be used to determine the range and mode of brain activation. After stroke, EA has been shown to alter brain connectivity, whereas EA's effect on brain network topology properties remains unclear. An evaluation of EA's effects on global and nodal topological properties in rats with ischemia reperfusion was conducted in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>There were three groups of adult male Sprague\u2010Dawley rats: sham\u2010operated group (sham group), middle cerebral artery occlusion\/reperfusion (MCAO\/R) group, and MCAO\/R plus EA (MCAO\/R\u00a0+\u00a0EA) group. The differences in global and nodal topological properties, including shortest path length, global efficiency, local efficiency, small\u2010worldness index, betweenness centrality (BC), and degree centrality (DC) were estimated. Graphical network analyses revealed that, as compared with the sham group, the MCAO\/R group demonstrated a decrease in BC value in the right ventral hippocampus and increased BC in the right substantia nigra, accompanied by increased DC in the left nucleus accumbens shell (AcbSh). The BC was increased in the right hippocampus ventral and decreased in the right substantia nigra after EA intervention, and MCAO\/R\u00a0+\u00a0EA resulted in a decreased DC in left AcbSh compared to MCAO\/R.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this study provide a potential basis for EA to promote cognitive and motor function recovery after ischemic stroke.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.3504","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T05:10:38Z","timestamp":1714713038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Electroacupuncture modulates abnormal brain connectivity after ischemia reperfusion injury in rats: A graph theory\u2010based approach"],"prefix":"10.1002","volume":"14","author":[{"given":"Si\u2010Si","family":"Li","sequence":"first","affiliation":[{"name":"School of Rehabilitation 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