{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:58:25Z","timestamp":1787756305305,"version":"build-2784847793"},"reference-count":60,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671316"],"award-info":[{"award-number":["81671316"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The inflammation and synaptic dysfunction induced by mitochondrial dysfunction play essential roles in the learning and memory impairment associated with sleep dysfunction. Elamipretide (SS\u201031), a novel mitochondrion\u2010targeted antioxidant, was proven to improve mitochondrial dysfunction, the inflammatory response, synaptic dysfunction, and cognitive impairment in models of cerebral ischemia, sepsis, and type 2 diabetes. However, the potential for SS\u201031 to improve the cognitive impairment induced by chronic sleep deprivation (CSD) and its underlying mechanisms is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult c57BL\/6J mice were subjected to CSD for 21 days using an activity wheel accompanied by daily intraperitoneal injection of SS\u201031 (5\u00a0mg\/kg). The novel object recognition and Morris water maze test were used to evaluate hippocampus\u2010dependent cognitive function. Western blotting and reverse transcription\u2010quantitative polymerase chain reaction assays were used to determine the effects of CSD and SS\u201031 on markers of mitochondria, inflammation response, and synaptic function. Enzyme\u2010linked immunosorbent assays were used to examine the levels of proinflammatory cytokines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SS\u201031 could improve the cognitive impairment induced by CSD. In particular, SS\u201031 treatment restored the CSD\u2010induced decrease in sirtuin 1 (SIRT1) and peroxisome proliferator\u2010activated receptor \u03b3 coactivator alpha levels and the increase in levels nuclear factor kappa\u2010B and inflammatory cytokines, including interleukin (IL)\u20101\u03b2, IL\u20106, and tumor necrosis factor\u2010alpha. Furthermore, SS\u201031 significantly increased the levels of brain\u2010derived neurotrophic factor, postsynaptic density protein\u201095, and synaptophysin in CSD mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Taken together, these results suggest that SS\u201031 could improve CSD\u2010induced mitochondrial biogenesis dysfunction, inflammatory response, synaptic dysfunction, and cognitive impairment by increasing SIRT1 expression levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3508","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T22:59:08Z","timestamp":1714517948000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Mitochondrial antioxidant elamipretide improves learning and memory impairment induced by chronic sleep deprivation in mice"],"prefix":"10.1002","volume":"14","author":[{"given":"Yue\u2010Ming","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology (Sleep Disorders) The Affiliated Chaohu Hospital of Anhui Medical University  Hefei Anhui P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology (Sleep Disorders) The Affiliated Chaohu Hospital of Anhui Medical University  Hefei Anhui P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9807-2015","authenticated-orcid":false,"given":"Ru\u2010Meng","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Neurology (Sleep Disorders) The Affiliated Chaohu Hospital of Anhui Medical University  Hefei Anhui P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1021-8340","authenticated-orcid":false,"given":"Xue\u2010Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology (Sleep Disorders) The Affiliated Chaohu Hospital of Anhui Medical University  Hefei Anhui P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao\u2010Ling","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Neurology (Sleep Disorders) The Affiliated Chaohu Hospital of Anhui Medical University  Hefei Anhui P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Ya","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology (Sleep Disorders) The Affiliated Chaohu Hospital of Anhui Medical University  Hefei Anhui P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai\u2010Xuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology (Sleep Disorders) The Affiliated Chaohu Hospital of Anhui Medical University  Hefei Anhui P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi\u2010Kun","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Neurology (Sleep Disorders) The Affiliated Chaohu Hospital of Anhui Medical University  Hefei Anhui P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue\u2010Chun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second People's Hospital of Hefei and Affiliated Hefei Hospital of Anhui Medical University  Hefei Anhui P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6816-9115","authenticated-orcid":false,"given":"Gui\u2010Hai","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology (Sleep Disorders) The Affiliated Chaohu Hospital of Anhui Medical University  Hefei Anhui P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2019.109832"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X21666230303123555"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110043"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175316"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012121216"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav3617"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2022.100478"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13105\u2010018\u20100617\u20101"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2023.02.023"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms12107199"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010023\u201005775\u20103"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22350"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065921"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064\u2010016\u20101937\u20106"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201034251\u20108"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27794"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules201219764"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S312272"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00162"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u201012\u2010801022\u20108.00014\u20103"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.05.014"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2022.12.002"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2013.155"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010021\u201001332\u20106"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7354"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11010027"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1980"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.2006.04018.x"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12972"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301596"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.04.549"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2020.08.010"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.1.285"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00025.2007"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12102"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2005.06.004"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1892"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010022\u201001909\u2010x"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.08.002"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.03.024"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389201024666230209142145"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature19773"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2022.1066725"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138256"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010014\u20108918\u2010z"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S310698"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1241224"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13218"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2022.127292"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.07.033"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031\u2010020\u201001612\u2010w"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064\u2010019\u201002831\u20103"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2016.12.034"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2022.943900"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2022.08.001"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010019\u20101627\u20109"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09663"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2010.03.017"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4783602"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.559182"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.3508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T04:09:01Z","timestamp":1721880541000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.3508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,30]]},"references-count":60,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/brb3.3508"],"URL":"https:\/\/doi.org\/10.1002\/brb3.3508","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.3508\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3508\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3508\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3508\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3508\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3508\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3508\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3508\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,30]]},"assertion":[{"value":"2023-08-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3508"}}