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This study aimed to assess the value of video oculomotor evaluation (VOE) in the differential diagnosis of MSA and Parkinson's disease (PD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 28 patients with MSA, 31 patients with PD, and 30 age\u2010 and sex\u2010matched healthy controls (HC) were screened and included in this study. The evaluation consisted of a gaze\u2010holding test, smooth pursuit eye movement (SPEM), random saccade, and optokinetic nystagmus (OKN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The MSA and PD groups had more abnormalities and decreased SPEM gain than the HC group (64.29%, 35.48%, 10%, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.001). The SPEM gain in the MSA group was significantly lower than that in the PD group at specific frequencies. Patients with MSA and PD showed prolonged latencies in all saccade directions compared with those with HC. However, the two diseases had no significant differences in the saccade parameters. The OKN gain gradually decreased from the HC to the PD and the MSA groups (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.05). Compared with the PD group, the gain in the MSA group was further decreased in the OKN test at 30\u00b0\/s (Left, <jats:italic>p\u00a0<\/jats:italic>=\u00a0.010; Right <jats:italic>p\u00a0<\/jats:italic>=\u00a0.016). Receiver operating characteristic curves showed that the combination of oculomotor parameters with age and course of disease could aid in the differential diagnosis of patients with MSA and PD, with a sensitivity of 89.29% and a specificity of 70.97%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combination of oculomotor parameters and clinical data may aid in the differential diagnosis of MSA and PD. Furthermore, VOE is vital in the identification of neurodegenerative diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.3510","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T05:58:46Z","timestamp":1715147926000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical value of video oculomotor evaluation in the differential diagnosis of multiple system atrophy and Parkinson's disease"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6193-006X","authenticated-orcid":false,"given":"Dongxiao","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat\u2010sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases National Key Clinical Department and Key Discipline of Neurology  Guangzhou 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