{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:02:41Z","timestamp":1772118161685,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011470","name":"Shanghai Minhang Science and Technology Commission","doi-asserted-by":"publisher","award":["2019MHZ081"],"award-info":[{"award-number":["2019MHZ081"]}],"id":[{"id":"10.13039\/501100011470","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973157"],"award-info":[{"award-number":["81973157"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173646"],"award-info":[{"award-number":["82173646"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The evidence for the association between white matter hyperintensity (WMH) severity and neurological deterioration (ND) in patients with single subcortical infarction (SSI) remains unclear and whether the association between them is modified by anterior circulation parent artery steno\u2010occlusion (PAS) is unknown. Herein, we aimed to prospectively investigate the internal relevance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective study, the severity of WMH and PAS were assessed in 288 consecutive patients with anterior circulation SSI arriving at our hospital, a tertiary teaching hospital affiliated with Fudan University, 24\u00a0h after onset from January 2017 to December 2018. The multivariable logistic regression model was used to estimate the association between WMH severity and the risk of ND within 7 days after stroke onset as well as the interactive effect between WMH severity and PAS on ND among patients with SSI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PAS modified the association between WMH severity and ND among patients with SSI (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>interaction<\/jats:sub>\n                      \u00a0=\u00a0.029). After multivariate adjustment, the odds ratios of moderate\u2010severe WMH associated with ND were 1.61 (95% CI, 0.50\u20135.19;\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>trend<\/jats:sub>\n                      \u00a0=\u00a0.428) for patients with PAS, and 0.37 (95% CI, 0.14\u20130.97;\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>trend<\/jats:sub>\n                      \u00a0=\u00a0.043) for those without PAS. Adding WMH severity to conventional risk factors improved risk prediction for ND in patients without PAS (net reclassification improvement: 48.2%,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a0.005; integrated discrimination index: 2.5%,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a0.004) but not in those with PAS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There was a modified effect of PAS on the association between WMH severity and ND within 7 days after stroke onset among patients with anterior circulation SSI, which deserves more research attention. WMH was negatively associated with ND in anterior circulation SSI patients without PAS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3523","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T10:08:41Z","timestamp":1715767721000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["White matter hyperintensity, parent artery steno\u2010occlusion, and neurological deterioration in anterior circulation single subcortical infarction patients"],"prefix":"10.1002","volume":"14","author":[{"given":"Yunhe","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Neurology Minhang Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daosheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Minhang Hospital Fudan University  Shanghai 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