{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:59:39Z","timestamp":1772117979817,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2501200"],"award-info":[{"award-number":["2021YFC2501200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Sequential working memory is the ability to maintain and manipulate sequential information at a second time scale. Patients with progressive supranuclear palsy (PSP) or Parkinson's disease (PD) perform poorly in tests that require the flexible arrangement of thoughts or actions. This study investigated whether sequential working memory is differently impaired in patients with PSP versus PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Twenty\u2010nine patients with PSP Richardson's syndrome (PSP\u2010RS), 36 patients with PD, and 36 healthy controls (HC) completed 3 well\u2010established neuropsychological tests, including digit span forward (DST\u2010F), digit span backward (DST\u2010B), and adaptive digit ordering tests (DOT\u2010A). The DST\u2010F required maintaining digit sequences, and the DST\u2010B and DOT\u2010A required maintaining and manipulating digit sequences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Finding<\/jats:title>\n                    <jats:p>The PSP\u2010RS group scored lower than the PD and HC groups in the DST\u2010B and DOT\u2010A but not in the DST\u2010F, indicating that the ability to manipulate sequences was impaired, but the maintenance ability was preserved in PSP\u2010RS patients. Moreover, in PSP\u2010RS, the DST\u2010B score negatively correlated with the severity of motor symptoms. The actual levodopa dose positively correlated with the DST\u2010B ordering cost (DST\u2010F score vs. DST\u2010B score). The PSP patients who took a greater dose of levodopa tended to have higher DST\u2010B ordering cost. There was no effect of levodopa on DST\u2010B or DOT\u2010A in PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results suggested that the ability to manipulate sequence was already reduced in patients with PSP\u2010RS and was worse than in patients with PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3527","type":"journal-article","created":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T01:44:49Z","timestamp":1714787089000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impaired sequence manipulation in non\u2010demented patients with progressive supranuclear palsy"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0965-218X","authenticated-orcid":false,"given":"Guanyu","family":"Zhang","sequence":"first","affiliation":[{"name":"China 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