{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:54:33Z","timestamp":1765976073354,"version":"3.41.2"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T00:00:00Z","timestamp":1433203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006095","name":"South-Eastern Norway Regional Health Authority","doi-asserted-by":"crossref","award":["2010091"],"award-info":[{"award-number":["2010091"]}],"id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Elevated blood pressure is frequently seen in acute stroke, and patients with lacunar and nonlacunar infarcts may have different underlying mechanisms for increase in blood pressure. The impact of hypertension as a risk factor may also vary. The aims of the present study were to investigate blood pressure in patients presenting with lacunar syndromes but with different anatomical subtypes of stroke, to explore the impact of subtype on blood pressure, and to identify stroke\u2010related factors associated with hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients presenting with an acute lacunar syndrome were enrolled. Patients were classified into a lacunar or nonlacunar group based on radiological verified infarcts. Blood pressure was measured. Between\u2010group differences were analyzed by <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u2010test, <jats:italic>t<\/jats:italic>\u2010test, and Mann\u2013Whitney <jats:italic>U<\/jats:italic> test, as appropriate. We performed linear regression to analyze the association between blood pressure and lacunar infarct, and multiple linear regression to adjust for other covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred thirteen patients were included. Seventy five percent had lacunar and 25% nonlacunar infarcts. There was no significant difference in clinical severity between the two groups. In the linear regression model, we found a significant association between blood pressure and lacunar infarct. No other factor was significantly associated with blood pressure in the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lacunar infarcts may be independently associated with higher blood pressure compared to nonlacunar infarcts with the same clinical severity. Blood pressure differences between different subtypes of stroke may not be related to clinical severity but to the underlying cause of stroke.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.353","type":"journal-article","created":{"date-parts":[[2015,6,3]],"date-time":"2015-06-03T00:54:14Z","timestamp":1433292854000},"source":"Crossref","is-referenced-by-count":19,"title":["Blood pressure differences between patients with lacunar and nonlacunar infarcts"],"prefix":"10.1002","volume":"5","author":[{"given":"Marianne","family":"Altmann","sequence":"first","affiliation":[{"name":"Department of Neurology Medical Division Akershus University Hospital L\u00f8renskog Norway"},{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bente","family":"Thommessen","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical Division Akershus University Hospital L\u00f8renskog Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole Morten","family":"R\u00f8nning","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical Division Akershus University Hospital L\u00f8renskog Norway"},{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antje S.","family":"Reichenbach","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical Division Akershus University Hospital L\u00f8renskog Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brynjar","family":"Fure","sequence":"additional","affiliation":[{"name":"Specialist Health Section The Norwegian Knowledge Centre for the Health Services Oslo Norway"},{"name":"Department of Geriatric Medicine Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.03.014"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.613752"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.4.1109"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.08.017"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.17.5.861"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.4.527"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.32.8.871"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.2.307"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093213"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.9.1726"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1994.tb01084.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000189624.06836.03"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.02189"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000157949.34986.30"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.558809"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355685"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2008.02022.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-9-44"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.14.3.332"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.723874"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/003693305700200504"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2004.10.004"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.2.211"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.5.604"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32833310e0"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000242781.80832.cc"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001662"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mbp.0000132424.48133.27"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1981.03320190035023"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.001894"},{"key":"e_1_2_7_32_1","first-page":"35","article-title":"Contribution of diffusion\u2010weighted imaging in determination of stroke etiology","volume":"27","author":"Wessels T.","year":"2006","journal-title":"AJNR Am. 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