{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:26:25Z","timestamp":1792092385306,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102022R1F1A1074160"],"award-info":[{"award-number":["NRF\u20102022R1F1A1074160"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Using correlation tractography, this study aimed to find statistically significant correlations between white matter (WM) tracts in participants with obstructive sleep apnea (OSA) and OSA severity. We hypothesized that changes in certain WM tracts could be related to OSA severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled 40 participants with OSA who underwent diffusion tensor imaging (DTI) using a 3.0 Tesla MRI scanner. Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), radial diffusivity (RD), and quantitative anisotropy (QA)\u2010values were used in the connectometry analysis. The apnea\u2010hypopnea index (AHI) is a representative measure of the severity of OSA. Diffusion MRI connectometry that was used to derive correlational tractography revealed changes in the values of FA, MD, AD, RD, and QA when correlated with the AHI. A false\u2010discovery rate threshold of 0.05 was used to select tracts to conduct multiple corrections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Connectometry analysis revealed that the AHI in participants with OSA was negatively correlated with FA values in WM tracts that included the cingulum, corpus callosum, cerebellum, inferior longitudinal fasciculus, fornices, thalamic radiations, inferior fronto\u2010occipital fasciculus, superior and posterior corticostriatal tracts, medial lemnisci, and arcuate fasciculus. However, there were no statistically significant results in the WM tracts, in which FA values were positively correlated with the AHI. In addition, connectometry analysis did not reveal statistically significant results in WM tracts, in which MD, AD, RD, and QA values were positively or negatively correlated with the AHI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Several WM tract changes were correlated with OSA severity. However, WM changes in OSA likely involve tissue edema and not neuronal changes, such as axonal loss. Connectometry analyses are valuable tools for detecting WM changes in sleep disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3541","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T02:19:04Z","timestamp":1716344344000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Correlation of diffusion tensor tractography with obstructive sleep apnea severity"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8999-386X","authenticated-orcid":false,"given":"Bong Soo","family":"Park","sequence":"first","affiliation":[{"name":"Departments of Internal Medicine, Haeundae Paik Hospital Inje University College of Medicine  Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Ah","family":"Lee","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Haeundae Paik Hospital Inje University College of Medicine  Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho\u2010Joon","family":"Lee","sequence":"additional","affiliation":[{"name":"Departments of Radiology, Haeundae Paik Hospital Inje University College of Medicine  Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinseung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Busan Paik Hospital Inje University College of Medicine  Busan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junghae","family":"Ko","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Haeundae Paik Hospital Inje University College of Medicine  Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurosurgey, Busan Paik Hospital Inje University College of Medicine  Busan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyae","family":"Yi","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Haeundae Paik Hospital Inje University College of Medicine  Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4229-7741","authenticated-orcid":false,"given":"Kang Min","family":"Park","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Haeundae Paik Hospital Inje University College of Medicine  Busan South 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