{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T01:14:50Z","timestamp":1788398090641,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Migraine\u2010related stigma (MiRS) and social burden is increasingly recognized. We assessed perspectives and attitudes toward migraine in people with and without migraine in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>OVERCOME (Japan) was a cross\u2010sectional, population\u2010based web survey of people with and without migraine (July\u2212September 2020). People with migraine were individuals who met the modified International Classification of Headache Disorders criteria or had self\u2010reported physician\u2010diagnosed migraine. People without migraine were selected per quota sampling to represent the Japanese adult population. People with migraine reported their experiences on stigma and social burden and answered how frequently they experienced stigma using the MiRS questionnaire. Associations between MiRS and disability and MiRS and interictal burden were examined using the migraine disability assessment and Migraine Interictal Burden Scale\u20104. People without migraine reported their experiences and attitudes toward people with migraine by answering an 11\u2010item attitudinal migraine questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 17,071 and 2008 people with and without migraine, respectively, completed the survey. Overall, 11,228 (65.8%) respondents with migraine reported that they have never experienced stigma or burden; however, of the 12,383 employed respondents, 5841 (47.2%) reported that their current employers are not \u201cextremely\u201d or \u201cvery\u201d understanding about their conditions. Moreover, \u223c30%\u221240% of respondents \u201csometimes,\u201d \u201coften,\u201d or \u201cvery often\u201d hid their migraine from others. The proportion of respondents who experienced stigma often or very often, as assessed by MiRS, was 16.5%; this increased with the increasing number of monthly migraine headache days. The proportion of respondents with moderate\u2010to\u2010severe disability and interictal burden increased with increasing stigma. Among respondents without migraine, the proportion holding a stigmatizing attitude toward those with migraine was low (&lt;15%); \u223c80% had never experienced work\u2010 or family\u2010related stigma or burden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MiRS and burden exist but may be hidden and underrecognized in Japan. Disease awareness and education may be important to prevent and reduce stigma and burden.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.3547","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T02:25:26Z","timestamp":1721960726000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Underrecognition of migraine\u2010related stigmatizing attitudes and social burden: Results of the OVERCOME Japan study"],"prefix":"10.1002","volume":"14","author":[{"given":"Hisaka","family":"Igarashi","sequence":"first","affiliation":[{"name":"Fujitsu Clinic  Kawasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1887-1296","authenticated-orcid":false,"given":"Mika","family":"Komori","sequence":"additional","affiliation":[{"name":"Japan Drug Development and Medical Affairs Eli Lilly Japan K.K. Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaname","family":"Ueda","sequence":"additional","affiliation":[{"name":"Japan Drug Development and Medical Affairs Eli Lilly Japan K.K. Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Zagar","sequence":"additional","affiliation":[{"name":"Real World and Access Analytics Eli Lilly and Company Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5134-037X","authenticated-orcid":false,"given":"Dena H.","family":"Jaffe","sequence":"additional","affiliation":[{"name":"Real World Evidence Cerner Enviza, an Oracle Company (formerly Kantar Health) Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Matsumori","sequence":"additional","affiliation":[{"name":"Sendai Headache and Neurology Clinic  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Takeshima","sequence":"additional","affiliation":[{"name":"Department of Neurology, Headache Center Tominaga Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Neurology Dokkyo Medical University Mibu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"A89","article-title":"Development and validation of the Migraine Interictal Burden Scale (MIBS): A self\u2010administered instrument for measuring the burden of migraine between attacks","volume":"68","author":"Buse D. 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