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Their dysfunction may be associated with disease progression in patients with Alzheimer's disease (AD), which is featured as progressive cognitive degeneration and asymmetric neuropathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to examine and define two inherent properties of hemispheric function in patients with AD by utilizing resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty\u2010four clinically diagnosed AD patients and 52 age\u2010 and sex\u2010matched cognitively normal subjects were recruited and underwent MRI and clinical evaluation. We calculated and compared brain specialization (autonomy index, AI) and interhemispheric cooperation (connectivity between functionally homotopic voxels, CFH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In comparison to healthy controls, patients with AD exhibited enhanced AI in the left middle occipital gyrus. This increase in specialization can be attributed to reduced functional connectivity in the contralateral region, such as the right temporal lobe. The CFH of the bilateral precuneus and prefrontal areas was significantly decreased in AD patients compared to controls. Imaging\u2010cognitive correlation analysis indicated that the CFH of the right prefrontal cortex was marginally positively related to the Montreal Cognitive Assessment score in patients and the Auditory Verbal Learning Test score. Moreover, taking abnormal AI and CFH values as features, support vector machine\u2010based classification achieved good accuracy, sensitivity, specificity, and area under the curve by leave\u2010one\u2010out cross\u2010validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study suggests that individuals with AD have abnormal cerebral specialization and interhemispheric cooperation. This provides new insights for further elucidation of the pathological mechanisms of AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3550","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T03:44:52Z","timestamp":1717645492000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Brain functional specialization and cooperation in Alzheimer's disease"],"prefix":"10.1002","volume":"14","author":[{"given":"Yue","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Neurology the First Affiliated Hospital of Anhui Medical University  Hefei Anhui Province China"},{"name":"Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders  Hefei Anhui Province China"},{"name":"Department of Psychology and Sleep Medicine the Second Hospital of Anhui Medical University  Hefei Anhui Province 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