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Neuromelanin\u2010sensitive magnetic resonance imaging (MRI) is an emerging method to index midbrain neuromelanin\u2014a by\u2010product of dopaminergic synthesis. The assessment of midbrain neuromelanin, and its association with AN psychopathology and reward\u2010related processes, may provide critical insights into reward circuit function in AN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study will incorporate neuromelanin\u2010sensitive MRI into an existing study of appetitive conditioning in those with AN. Specifically, those with acute and underweight AN (<jats:italic>N<\/jats:italic>\u00a0=\u00a030), those with weight\u2010restored AN (<jats:italic>N<\/jats:italic>\u00a0=\u00a030), and age\u2010matched healthy controls (<jats:italic>N<\/jats:italic>\u00a0=\u00a030) will undergo clinical assessment of current and previous psychopathology, in addition to structural neuromelanin\u2010sensitive MRI, diffusion MRI, and functional MRI (fMRI) during appetitive conditioning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study will be among the first to interrogate midbrain neuromelanin in AN\u2014a disorder characterized by altered dopaminergic activity. Results will help establish whether abnormalities in the midbrain synthesis of dopamine are evident in those with AN and are associated with symptomatic behavior and reduced ability to experience pleasure and reward.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.3573","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T04:53:09Z","timestamp":1718859189000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessing midbrain neuromelanin and its relationship to reward learning in anorexia nervosa: Stage 1 of a registered report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5588-2915","authenticated-orcid":false,"given":"Stuart B.","family":"Murray","sequence":"first","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Sciences University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel P.","family":"Diaz\u2010Fong","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health  Toronto Ontario Canada"},{"name":"Institute of Medical Science, Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Semel Institute for Neuroscience &amp; Human Behavior, Department of Psychiatry &amp; Biobehavioral Science University of California, Los Angeles  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vienna W. 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