{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:02:15Z","timestamp":1772118135116,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the potential of magnetic resonance imaging (MRI)\u2010based total and segmental hippocampus volume analysis in the assessment of cognitive status in Parkinson's disease (PD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We divided participants into three groups Group A\u2010Parkinson patients (Pp) with normal cognitive status (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a025), Group B\u2010Pp with dementia (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a017), and Group C\u2010healthy controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a037). Three\u2010dimensional T1W Fast Spoiled Gradient Recalled Echo images were used for Volbrain hippocampus subfield segmentation. We used the \u201cWinterburn\u201d protocol, which divides the hippocampus into five segments, Cornu Ammonis (CA),CA2\/CA3, CA4\/dentate gyrus, stratum radiatum, lacunosum, and moleculare, and subiculum.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 79 participants were included in the study, consisting of 42 individuals with PD (64.2% male) and 37 healthy controls (54.1% male). The mean age of PD was 60.9\u00a0\u00b1\u00a010.7 years and the mean age of control group was 59.27\u00a0\u00b1\u00a012.3 years. Significant differences were found in total hippocampal volumes between Group A and B (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.047. Statistically significant group differences were found in total, right, and left CA1 volumes (analysis of variance [ANOVA]:\n                      <jats:italic>F<\/jats:italic>\n                      (2,76)\u00a0=\u00a08.098,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.001;\n                      <jats:italic>F<\/jats:italic>\n                      (2,76)\u00a0=\u00a07.628,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.001;\n                      <jats:italic>F<\/jats:italic>\n                      (2,76)\u00a0=\u00a05.084,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.008, respectively), as well as in total subiculum volumes (ANOVA:\n                      <jats:italic>F<\/jats:italic>\n                      (2,76)\u00a0=\u00a04.368,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.016). Post hoc tests showed that total subiculum volume was significantly lower in individuals with normal cognitive status (0.474\u00a0\u00b1\u00a00.116\u00a0cm\n                      <jats:sup>3<\/jats:sup>\n                      ) compared to healthy controls (0.578\u00a0\u00b1\u00a00.151\u00a0cm\n                      <jats:sup>3<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.013).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Volumetric hippocampal MRI can be used to assess the cognitive status of Pp. Longitudinal studies that evaluate Pp who progress from normal cognition to dementia are required to establish a causal relationship.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3576","type":"journal-article","created":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T00:28:56Z","timestamp":1720225736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the cognitive assessment potential of MRI\u2010based volumetric hippocampal segmentation in Parkinson's disease"],"prefix":"10.1002","volume":"14","author":[{"given":"Merve","family":"Tarhan","sequence":"first","affiliation":[{"name":"Department of Radiology Istanbul Medeniyet University G\u00f6ztepe Training and Research Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ba\u015fak","family":"Atalay","sequence":"additional","affiliation":[{"name":"Department of Radiology Istanbul Medeniyet University G\u00f6ztepe Training and Research Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1324-2810","authenticated-orcid":false,"given":"Ay\u015fenur","family":"Buz Ya\u015far","sequence":"additional","affiliation":[{"name":"Department of Radiology \u0130zzet Baysal State Hospital  Bolu Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma Bet\u00fcl","family":"\u00d6zdilek","sequence":"additional","affiliation":[{"name":"Department of Neurology Istanbul Medeniyet University G\u00f6ztepe Training and Research Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010019\u201006043\u20109"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.03.050"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm111"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2016.12.008"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10444"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702\u2010017\u20101717\u20108"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3233\/jpd\u2010150733"},{"key":"e_1_2_12_9_1","unstructured":"Tsochatzis T. Velonakis G. Toulas P. Papathanasiou M. A. Karavasilis E. &Pantoleon V.(2019).Role of MRI in the differential diagnosis of Parkinson Disease and Parkinson Plus Syndromes(C\u20102501 ECR).European Society of Radiology."},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010180250"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.7157\/jprls.2012.v2n1pp6\u201010"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(07)70178\u20103"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21507"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24893"},{"key":"e_1_2_12_15_1","volume-title":"Neuropsychological assessment","author":"Lezak M. 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