{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:13:07Z","timestamp":1788199987057,"version":"build-2803163510"},"reference-count":68,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The research intended to probe the connection between the risk of stroke and serum vitamin D levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three electronic databases (Cochrane Library, EMBASE, PubMed) were searched according to the subject terms from inception until July 29, 2022, and retrieved researches were screened on the basis of inclusion and exclusion criteria. Two investigators conducted the quality assessment and data extraction. Using Stata 16.0 software, a meta\u2010analysis was conducted on the extracted data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>In total, 27 studies with 45,302 participants were included. Among these studies, 20 focused on stroke risk, while 7 examined stroke prognosis. According to the meta\u2010analysis findings, it was observed that a higher stroke risk is connected to reduced levels of serum vitamin D. This association was reflected in a combined relative risk (RR) of 1\u00a0.28 (95% confidence interval (CI): 1.15\u20131.42) and a worse prognosis after stroke (RR\u00a0=\u00a02.95, 95% CI: 1.90\u20134.60). Additional analysis indicated that no apparent relationship between a decrease in vitamin D and the probability of experiencing a hemorrhagic stroke was found. The RR found was 1.93 (95% CI: 0.95\u20133.95). On the other hand, it was observed that a reduction in serum vitamin D levels was linked to an elevated likelihood of developing an ischemic stroke. The RR identified was 1.72 (95% CI: 1.78\u20132.03). Moreover, a lower level of vitamin D in the bloodstream was associated with a more unfavorable prognosis for individuals who suffered from a stroke. The RR for this correlation was 2.95 (95% CI: 1.90\u20134.60). However, further research is required to confirm the above\u2010mentioned findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, lower concentration vitamin D was found to be related to an increased risk of stroke, which could mainly be reflected in ischemic stroke patients but not in patients with hemorrhagic stroke. A lower serum vitamin D level was correlative with the poor prognosis of stroke.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3577","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T05:54:23Z","timestamp":1718344463000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A systematic review and meta\u2010analysis of the linkage between low vitamin D and the risk as well as the prognosis of stroke"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4515-5159","authenticated-orcid":false,"given":"Jianrong","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine Fourth Affiliated Hospital of Zhejiang University Medical College Yiwu Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenliang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Intensive Care Medicine Heyou Hospital, Foshan Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Chinese Medicine &amp; Rehabilitation Medicine The Second Affiliated Hospital of Zhejiang University Medical College Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Fourth Affiliated Hospital of Zhejiang University Medical College Yiwu Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011\u2010016\u20109939\u20102"},{"issue":"24","key":"e_1_2_10_3_1","first-page":"00","article-title":"Vitamin D and vitamin D\u2010related diseases in Greenland","volume":"182","author":"Andersen S.","year":"2020","journal-title":"Ugeskrift for Laeger"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.05.027"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.670245"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665117004153"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28424"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010019\u20100118\u20108"},{"key":"e_1_2_10_9_1","volume-title":"Committee to review dietary reference intakes for vitamin D and calcium food and nutrition board","author":"Catharine Ross A."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.551341"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.6.1689S"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq246"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17719208"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12017\u2010018\u20108484\u2010z"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.082602"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.970111"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2013.1734"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(19)30034\u20101"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00480"},{"key":"e_1_2_10_20_1","unstructured":"Higgins J. &Green S.(2011).Cochrane handbook for systematic reviews for interventions(Version 5.1.0). 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