{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:50:12Z","timestamp":1788587412163,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T00:00:00Z","timestamp":1721520000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006546","name":"Angelini Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006546","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Health\u2010related quality of life (HRQL) is an important goal for patients with major depressive disorder (MDD), but whether antidepressants improve HRQL in these patients is unclear. Here, we describe the real\u2010world effects of trazodone once\u2010a\u2010day (TzOAD) and selective serotonin reuptake inhibitor (SSRI) treatments on HRQL and functioning in adults with MDD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This 8\u2010week prospective, observational, open\u2010label, multicenter study was conducted in adults with moderate or severe MDD for whom TzOAD or SSRI were prescribed as monotherapy. The primary outcome was life enjoyment and satisfaction assessed via the patient\u2010reported Quality\u2010of\u2010Life Enjoyment and Satisfaction Questionnaire Short Form (Q\u2010LES\u2010Q\u2010SF) from baseline to week 8. Secondary outcomes included change in Q\u2010LES\u2010Q\u2010SF from baseline to weeks 1 and 2; severity of depressive symptoms using the Montgomery \u00c5sberg Depression Rating Scale (MADRS) and sleep disturbance via the PROMIS SF\u2010SD 8b questionnaire at weeks 1, 2, and 8; and overall functioning via the Sheehan Disability Scale (SDS), hedonic capacity using the Snaith\u2013Hamilton Pleasure Scale (SHAPS), and cognitive dysfunction using the Perceived Deficits Questionnaire (PDQ\u20105) at baseline and week 8.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 208 adults with MDD (mean [SD] age\u00a0=\u00a050.2 [14.3] years; 68.6% female; 98.4% White). Life enjoyment and satisfaction improved from baseline to week 8 for both treatment groups: Q\u2010LES\u2010Q\u2010SF mean (SD) scores were 27.5 (20.4) for the SSRI group and 39.0 (22.1) for the TzOAD group. Depressive symptoms and sleep disturbances also reduced from baseline to week 8: MADRS (SSRI, \u221215.7 [8.3]; TzOAD, \u221221.0 [9.8]); PROMIS SF\u2010SD 8b (SSRI, \u22129.9 [12.6]; TzOAD, \u221222.0 [12.6]). Mean change scores in Q\u2010LES\u2010Q\u2010SF, MADRS, and PROMIS SF\u2010SD 8b improved as early as week 1 in both groups. Mean scores also improved from baseline to week 8 on SDS (SSRI, \u22129.2 [7.4]; TzOAD, \u221214.3 [7.5]), SHAPS (SSRI, \u22126.6 [4.3]; TzOAD, \u22128.3 [4.4]), and PDQ\u20105 (SSRI, \u22125.8 [4.5]; TzOAD, \u22127.7 [5.0]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In adults with MDD who received TzOAD or SSRIs, overall and individual HQRL domains improved rapidly and in parallel with improvements in depressive symptoms, with a slightly greater improvement observed in the TzOAD group.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.3580","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T02:59:18Z","timestamp":1721617158000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of trazodone once\u2010a\u2010day on quality of life and functional recovery in adults with major depressive disorder: A prospective, observational study"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5086-9586","authenticated-orcid":false,"given":"Valeria","family":"Tellone","sequence":"first","affiliation":[{"name":"Global Medical Department Angelini Pharma S.p.A.  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Stredocesk\u00fd kraj Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Strashimirova","sequence":"additional","affiliation":[{"name":"Diagnostic Consultative Center 14 Hospital VITA  Sofia Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Sani","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Section of Psychiatry Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"},{"name":"Department of Neuroscience, Sensory Organs and Thorax, UOC Psichiatria Clinica e D'Urgenza Fondazione Policlinico Universitario A Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Lenderking","sequence":"additional","affiliation":[{"name":"Evidera\u2010PPD  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Kay","family":"Margolis","sequence":"additional","affiliation":[{"name":"Evidera\u2010PPD  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Fallone","sequence":"additional","affiliation":[{"name":"Global Medical Department Angelini Pharma S.p.A.  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