{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T18:43:36Z","timestamp":1788633816342,"version":"build-2803163510"},"reference-count":104,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T00:00:00Z","timestamp":1717718400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Premature ejaculation (PE), a common male sexual dysfunction, often accompanies by abnormal psychological factors, such as depression. Recent neuroimaging studies have revealed structural and functional brain abnormalities in PE patients. However, there is limited neurological evidence supporting the comorbidity of PE and depression. This study aimed to explore the topological changes of the functional brain networks of PE patients with depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI) data were acquired from 60 PE patients (30 with depression and 30 without depression) and 29 healthy controls (HCs). Functional brain networks were constructed for all participants based on rs\u2010fMRI data. The nodal parameters including nodal centrality and efficiency were calculated by the method of graph theory analysis and then compared between groups. In addition,\u00a0the results\u00a0were\u00a0corrected\u00a0for multiple comparisons by family\u2010wise error (FWE) (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PE patients with depression had increased degree centrality and global efficiency in the right pallidum, as well as increased degree centrality in the right thalamus when compared with HCs. PE patients without depression showed increased degree centrality in the right pallidum and thalamus, as well as increased global efficiency in the right precuneus, pallidum, and thalamus when compared with HCs. PE patients with depression demonstrated decreased degree centrality in the right pallidum and thalamus, as well as decreased global efficiency in the right precuneus, pallidum, and thalamus when compared to those without depression. All the brain regions above survived the FWE correction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results suggested that increased and decreased functional connectivity, as well as the capability of global\u00a0integration\u00a0of\u00a0information in the brain, might be related to the occurrence of PE and the comorbidity depression in PE patients, respectively. These findings provided new insights into the understanding of the pathological mechanisms underlying PE and those with depression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.3585","type":"journal-article","created":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T03:53:19Z","timestamp":1717818799000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Topological differences of striato\u2010thalamo\u2010cortical circuit in functional brain network between premature ejaculation patients with and without depression"],"prefix":"10.1002","volume":"14","author":[{"given":"Xinyue","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Medicine &amp; Holistic Integrative Medicine Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peining","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Andrology Siyang County Traditional Chinese Medicine Hospital Affiliated to Yangzhou University School of Medicine  Suqiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqing","family":"Su","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, School of Integrated Chinese and Western Medicine Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, School of Integrated Chinese and Western Medicine Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunke","family":"Huang","sequence":"additional","affiliation":[{"name":"Women's Hospital Zhejiang University School of Medicine  Zhejiang 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