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GWAS data for MS were obtained from the International Multiple Sclerosis Genetics Consortium (IMSGC) for primary analysis and the FinnGen consortium for replication and collaborative analysis. Sensitivity analyses were conducted to evaluate heterogeneity and pleiotropy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After inverse\u2010variance\u2010weighted and sensitivity analysis filtering, seven gut microbiota with potential causal effects on MS were identified from the IMSGC. Only five metabolites remained significant associations with MS when combined with the FinnGen consortium, including genus <jats:italic>Anaerofilum id.2053<\/jats:italic> (odds ratio [OR]\u00a0=\u00a01.141, 95% confidence interval [CI]: 1.021\u20131.276, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.021), <jats:italic>Ruminococcus2 id.11374<\/jats:italic> (OR\u00a0=\u00a01.190, 95% CI: 1.007\u20131.406, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.042), <jats:italic>Ruminococcaceae UCG003 id.11361<\/jats:italic> (OR\u00a0=\u00a00.822, 95% CI: 0.688\u20130.982, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.031), <jats:italic>Ruminiclostridium5 id.11355<\/jats:italic> (OR\u00a0=\u00a00.724, 95% CI: 0.585\u20130.895, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.003), <jats:italic>Anaerotruncus id.2054<\/jats:italic> (OR\u00a0=\u00a00.772, 95% CI: 0.634\u20130.940, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.010).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our MR analysis reveals a potential causal relationship between gut microbiota and MS, offering promising avenues for advancing mechanistic understanding and clinical investigation of microbiota\u2010mediated MS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.3593","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T04:59:10Z","timestamp":1718859550000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Causal effects of gut microbiota on multiple sclerosis: A two\u2010sample Mendelian randomization study"],"prefix":"10.1002","volume":"14","author":[{"given":"Dongren","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Neurology West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology West China Hospital Sichuan 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