{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:02:22Z","timestamp":1772118142943,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T00:00:00Z","timestamp":1719705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2501200"],"award-info":[{"award-number":["2021YFC2501200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Semantic fluency is the ability to name items from a given category within a limited time, which relies on semantic knowledge, working memory, and executive function. Similar to patients with Parkinson's disease (PD), patients with progressive supranuclear palsy (PSP) scored lower than healthy adults in the well\u2010established semantic fluency test. However, it is unclear how unique are the produced words. This study examined the relationship between semantic fluency and words\u2019 uniqueness in patients with PSP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010seven patients with PSP Richardson's syndrome (PSP\u2010RS), 37 patients with PD, and 41 healthy controls (HC) performed a standard semantic fluency test (animals), and their verbal responses were audio\u2010recorded. We used the uniqueness to reflect the ability to produce both original and effective work, that is, creativity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The PSP\u2010RS group produced fewer correct words and fewer unique words than the PD and HC groups. Moreover, the correlation between fluency and uniqueness was positive in the HC and PD groups but negative in the PSP\u2010RS group. Importantly, the actual levodopa dose was positively correlated with the fluency but negatively correlated with the uniqueness in PSP\u2010RS. The PSP\u2010RS patients who took a greater dose of levodopa tended to produce more correct words but fewer unique words.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results suggested that levodopa may modulate semantic fluency and uniqueness in the early stages of PSP\u2010RS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3606","type":"journal-article","created":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T21:58:55Z","timestamp":1719784735000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Levodopa modulates semantic fluency and uniqueness in non\u2010demented patients with progressive supranuclear palsy"],"prefix":"10.1002","volume":"14","author":[{"given":"Jinghong","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Neurology Xuanwu Hospital of Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0965-218X","authenticated-orcid":false,"given":"Guanyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"China Institute of Sport Science  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Center The Fourth People's Hospital of Shenyang  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piu","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Ye","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Center for Excellence 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