{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:51:22Z","timestamp":1788385882370,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82021002"],"award-info":[{"award-number":["82021002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81830063"],"award-info":[{"award-number":["81830063"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072539"],"award-info":[{"award-number":["82072539"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013105","name":"Shanghai Rising-Star Program","doi-asserted-by":"publisher","award":["23QA1400800"],"award-info":[{"award-number":["23QA1400800"]}],"id":[{"id":"10.13039\/501100013105","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Central nervous system (CNS) disorders, such as stroke, often lead to spasticity, which result in limb deformities and significant reduction in quality of life. Spasticity arises from disruptions in the normal functioning of cortical and descending inhibitory pathways in the brainstem, leading to abnormal muscle contractions. Contralateral seventh cervical nerve cross transfer (CC7) surgery has been proven to effectively reduce spasticity, but the specific mechanism for its effectiveness is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study aimed to investigate the changes in the dorsal root ganglia (DRG) following CC7 surgery. A comprehensive anatomical analysis was conducted through cadaveric study and magnetic resonance imaging (MRI) study, to accurately measure the regional anatomy of the C7 DRG. DRG perfusion changes were quantitatively assessed by comparing pre\u2010 and postoperative dynamic contrast\u2010enhanced (DCE) MRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In CC7 surgery, the C7 nerve root on the affected side is cut close to the DRG (3.6\u00a0\u00b1\u00a01.0\u00a0mm), while the C7 nerve root on the healthy side is cut further away from the DRG (65.0\u00a0\u00b1\u00a010.0\u00a0mm). MRI studies revealed that after C7 proximal neurotomy on the affected side, there was an increase in DRG volume, vascular permeability, and perfusion; after C7 distal neurotomy on the healthy side, there was a decrease in DRG volume, with no significant changes in vascular permeability and perfusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study provides preliminary insights into the mechanisms of spasticity reduction following CC7 surgery, indicating that changes in the DRG, such as increased vascular permeability and perfusion, could disrupt abnormal spinal\n                      <jats:italic>\u03b3<\/jats:italic>\n                      \u2010circuits. The resulting high\u2010perfusion state of DRG, possibly due to heightened neuronal activity and metabolic demands, necessitating further research to verify this hypothesis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3613","type":"journal-article","created":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T01:00:31Z","timestamp":1720227631000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Unveiling the role of dorsal root ganglia in spasticity reduction: Insights from contralateral seventh cervical nerve cross transfer surgery"],"prefix":"10.1002","volume":"14","author":[{"given":"Xuanyu","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Hand and Upper Extremity Surgery, Jing'an District Central Hospital, Branch of Huashan Hospital, the National Clinical Research Center for Aging and Medicine Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1653-8070","authenticated-orcid":false,"given":"Xingyi","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Hand and Upper Extremity Surgery, Jing'an District Central Hospital, Branch of Huashan Hospital, the National Clinical Research Center for Aging and Medicine Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huali","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology, Jing'an District Central Hospital, Branch of Huashan Hospital, the National Clinical Research Center for Aging and Medicine Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hand and Upper Extremity Surgery, Jing'an District Central Hospital, Branch of Huashan Hospital, the National Clinical Research Center for Aging and Medicine Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqun","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Hand and Upper Extremity Surgery, Jing'an District Central Hospital, Branch of Huashan Hospital, the National Clinical Research Center for Aging and Medicine Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yundong","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Hand and Upper Extremity Surgery, Jing'an District Central Hospital, Branch of Huashan Hospital, the National Clinical Research Center for Aging and Medicine Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7979-3784","authenticated-orcid":false,"given":"Juntao","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Hand and Upper Extremity Surgery, Jing'an District Central Hospital, Branch of Huashan Hospital, the National Clinical Research Center for Aging and Medicine Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hand and Upper Extremity Surgery, Jing'an District Central Hospital, Branch of Huashan Hospital, the National Clinical Research Center for Aging and Medicine Fudan University  Shanghai China"},{"name":"Institute of Brain Science, State Key Laboratory of Medical Neurobiology and Collaborative Innovation Center for Brain Science Fudan University  Shanghai China"},{"name":"Research Unit of Synergistic Reconstruction of Upper and Lower Limbs after Brain Injury Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Co\u2010innovation Center of Neuroregeneration Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10153344"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro\u20102021\u20100122"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2000.93.1.0026"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/57.4.371"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.208593"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010017\u20104976\u20108"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(21)00252\u20100"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1533\u20102500.2002.02035.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361\u20109230(93)90249\u2010b"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311\u2010018\u201000690\u20104"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.101258"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25018"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000004396"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.07.030"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hansur.2017.06.009"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.04.042"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744\u20108069\u20104\u201010"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2021.106715"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00590\u2010017\u20102026\u20105"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2016.90"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/15459683211011214"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2006.104.2.215"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-95730-8_26"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0896\u20106273(02)00702\u2010x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0896\u20106273(00)80755\u20102"},{"issue":"4","key":"e_1_2_8_27_1","first-page":"119","article-title":"Selective posterior rhizotomy for the relief of spasticity in cerebral palsy","volume":"62","author":"Peacock W. J.","year":"1982","journal-title":"South African Medical Journal"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2021.06.087"},{"issue":"1","key":"e_1_2_8_29_1","first-page":"95","article-title":"External loops of human premotor spinal oscillators identified by simultaneous measurements of interspike intervals and phase relations","volume":"15","author":"Schalow G.","year":"1996","journal-title":"General Physiology and Biophysics"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hcl.2018.07.002"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102377\u201010\u201052"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e318241ace1"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/ons\/opaa325"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.20877"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1460"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1615208"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.3613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T12:54:10Z","timestamp":1722257650000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.3613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/brb3.3613"],"URL":"https:\/\/doi.org\/10.1002\/brb3.3613","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.3613\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3613\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3613\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3613\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3613\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3613\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3613\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3613\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3613\/v1\/review3","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2023-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3613"}}