{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:59:51Z","timestamp":1777885191311,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301458"],"award-info":[{"award-number":["82301458"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2501400"],"award-info":[{"award-number":["2021YFC2501400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2501404"],"award-info":[{"award-number":["2021YFC2501404"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3600500"],"award-info":[{"award-number":["2022YFC3600500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3600503"],"award-info":[{"award-number":["2022YFC3600503"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The right posterior parietal cortex is the core brain region of emotional processing and executive control network in the human brain, and the function of the right posterior parietal cortex is decreased in patients with major depressive disorder. This study aims to preliminarily investigate whether the excitation of the right posterior parietal cortex by transcranial direct current stimulation (tDCS) could improve their clinical symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, 12 patients with major depressive disorder were given tDCS treatment at Xuanwu Hospital of Capital Medical University and the First Hospital of Hebei Medical University. The stimulating electrode (anode) was placed on the patients\u2019 right parietal cortex, whereas the reference electrode (cathode) was placed on the patients\u2019 left mastoid. The stimulation intensity was set as 2.0\u00a0mA. The patients with depressive disorder were treated for 20\u00a0min at a time twice a day for 14 consecutive days. The severity of the clinical symptoms was evaluated using the Hamilton Depression Rating Scale\u201017 (HDRS\u201017) and the Hamilton Anxiety Rating Scale (HARS) at before and right after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The HDRS\u201017 scores of patients with depressive disorder decreased significantly following the tDCS treatment compared with those before treatment (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.001). Further analysis revealed that the patients\u2019 anxiety\/somatization, cognitive deficit, retardation, and sleep disorder scores all decreased significantly after the tDCS treatment (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.05), although there was no significant change in their weight. Moreover, the patients\u2019 HARS scores decreased significantly after the tDCS treatment when compared with those before treatment (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The right parietal cortex may be another key stimulation targets to improving the efficacy of tDCS treatment to the patients with major depressive disorder.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.3638","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T07:34:51Z","timestamp":1722843291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Transcranial direct current stimulation over the right parietal cortex improves the depressive disorder: A preliminary study"],"prefix":"10.1002","volume":"14","author":[{"given":"Xin","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Neurology The First Hospital of Hebei Medical University  Shijiazhuang Hebei China"},{"name":"Department of Neurology Hebei Hospital, Xuanwu Hospital, Capital Medical University  Shijiazhuang China"},{"name":"Neuromedical Technology Innovation Center of Hebei Province  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qilin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Department of Neurology Fuwai Hospital, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueying","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology The First Hospital of Hebei Medical University  Shijiazhuang Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhexue","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology Xuanwu Hospital 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