{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:32:21Z","timestamp":1792096341931,"version":"4.4.0"},"reference-count":81,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["21JCZDJC00880"],"award-info":[{"award-number":["21JCZDJC00880"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860109"],"award-info":[{"award-number":["81860109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170558"],"award-info":[{"award-number":["82170558"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Depressive symptoms are frequently observed in patients with primary biliary cholangitis (PBC). The role of depressive symptoms on cirrhosis has not been fully noticed in PBC. We aimed to establish a risk model for cirrhosis that took depressive symptoms into account.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Depressive symptoms were assessed by the 17\u2010item Hamilton Depression Rating Scale (HAMD\u201017). HAMD\u201017 score was analyzed in relation to clinical parameters. Least absolute shrinkage and selection operator (Lasso)\u2010logistic regression and decision tree models were used to explore the effect of depressive symptoms on cirrhosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The rate of depressive symptom in patients with PBC (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0162) was higher than in healthy controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0180) (52.5%\u00a0vs. 16.1%;\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a0.001). HAMD\u201017 score was negatively associated with C4 levels and positively associated with levels of alkaline phosphatase (ALP), \u03b3\u2010glutamyl transpeptidase (GGT), total bilirubin (TB), Immunoglobulin (Ig) G, and IgM (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.162, 0.197, 0.355, 0.203, 0.182, 0.314,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a0.05). In Lasso\u2010logistic regression analysis, HAMD\u201017 score,\n                      <jats:italic>human leukocyte antigen (HLA)\u2010DRB1*03:01<\/jats:italic>\n                      allele, age, ALP levels, and IgM levels (odds ratio [OR]\u00a0=\u00a01.087, 7.353, 1.075, 1.009, 1.005;\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.05) were independent risk factors for cirrhosis. Elevated HAMD\u201017 score was also a discriminating factor for high risk of cirrhosis in patients with PBC in decision tree model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Depressive symptoms were associated with disease severity. Elevated HAMD\u201017 score was a risk factor for cirrhosis in patients with PBC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3639","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T03:39:03Z","timestamp":1722829143000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Depressive symptom as a risk factor for cirrhosis in patients with primary biliary cholangitis: Analysis based on Lasso\u2010logistic regression and decision tree models"],"prefix":"10.1002","volume":"14","author":[{"given":"Simin","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, General Hospital Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, General Hospital Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangpeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, General Hospital Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijing","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, General Hospital Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, General Hospital Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ran","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, General Hospital Tianjin Medical University  Tianjin 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