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Source current densities of event\u2010related potentials to the first utterance in the pair were estimated and effects of stimulus\u2013response combinations, brain area, hemisphere, and clarity of visual articulation were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Auditory cortex, superior parietal cortex, and middle temporal cortex were the most consistently involved areas across experimental conditions. Early (&lt;200\u00a0msec) processing of the consonant was overall prominent in the left hemisphere, except right hemisphere prominence in superior parietal cortex and secondary visual cortex. Clarity of visual articulation impacted activity in secondary visual cortex and Wernicke's area. McGurk perception was associated with decreased activity in primary and secondary auditory cortices and Wernicke's area before 100\u00a0msec, increased activity around 100\u00a0msec which decreased again around 180\u00a0msec. Activity in Broca's area was unaffected by McGurk perception and was only increased to congruent audio\u2010visual stimuli 30\u201370\u00a0msec following consonant onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results suggest left hemisphere prominence in the effects of stimulus and response conditions on eight brain areas involved in dynamically distributed parallel processing of audio\u2010visual integration. Initially (30\u201370\u00a0msec) subcortical contributions to auditory cortex, superior parietal cortex, and middle temporal cortex occur. During 100\u2013140\u00a0msec, peristriate visual influences and Wernicke's area join in the processing. Resolution of incongruent audio\u2010visual inputs is then attempted, and if successful, McGurk perception occurs and cortical activity in left hemisphere further increases between 170 and 260\u00a0msec.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.407","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T10:52:04Z","timestamp":1444906324000},"source":"Crossref","is-referenced-by-count":8,"title":["Spatio\u2010temporal distribution of brain activity associated with audio\u2010visually congruent and incongruent speech and the McGurk Effect"],"prefix":"10.1002","volume":"5","author":[{"given":"Hillel","family":"Pratt","sequence":"first","affiliation":[{"name":"Evoked Potentials Laboratory Technion \u2010 Israel Institute of Technology Haifa 32000 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Bleich","sequence":"additional","affiliation":[{"name":"Evoked Potentials Laboratory Technion \u2010 Israel Institute of Technology Haifa 32000 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nomi","family":"Mittelman","sequence":"additional","affiliation":[{"name":"Evoked Potentials Laboratory Technion \u2010 Israel Institute of Technology Haifa 32000 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000059865.32155.86"},{"key":"e_1_2_8_3_1","first-page":"88","volume-title":"Disorders of human communication 2","author":"Albert M. 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