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These studies have shown that the network underlying reaching\u2010only and reach\u2010to\u2010grasp movements includes the superior parieto\u2010occipital cortex (<jats:styled-content style=\"fixed-case\">SPOC<\/jats:styled-content>), the anterior part of the human intraparietal sulcus (<jats:styled-content style=\"fixed-case\">hAIP<\/jats:styled-content>), the ventral and the dorsal portion of the premotor cortex, and the primary motor cortex (<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>1). Recent evidence for a wider frontoparietal network coding for different aspects of reaching\u2010only and reach\u2010to\u2010grasp actions calls for a more fine\u2010grained assessment of the reaching\u2013grasping network in humans by exploiting pattern decoding methods (multivoxel pattern analysis\u2014<jats:styled-content style=\"fixed-case\">MVPA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Here, we used<jats:styled-content style=\"fixed-case\">MPVA<\/jats:styled-content>on functional magnetic resonance imaging (f<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) data to assess whether regions of the frontoparietal network discriminate between reaching\u2010only and reach\u2010to\u2010grasp actions, natural and constrained grasping, different grasp types, and object sizes. Participants were required to perform either reaching\u2010only movements or two reach\u2010to\u2010grasp types (precision or whole hand grasp) upon spherical objects of different sizes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivoxel pattern analysis highlighted that, independently from the object size, all the selected regions of both hemispheres contribute in coding for grasp type, with the exception of<jats:styled-content style=\"fixed-case\">SPOC<\/jats:styled-content>and the right h<jats:styled-content style=\"fixed-case\">AIP<\/jats:styled-content>. Consistent with recent neurophysiological findings on monkeys, there was no evidence for a clear\u2010cut distinction between a dorsomedial and a dorsolateral pathway that would be specialized for reaching\u2010only and reach\u2010to\u2010grasp actions, respectively. Nevertheless, the comparison of decoding accuracy across brain areas highlighted their different contributions to reaching\u2010only and grasping actions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Altogether, our findings enrich the current knowledge regarding the functional role of key brain areas involved in the cortical control of reaching\u2010only and reach\u2010to\u2010grasp actions in humans, by revealing novel fine\u2010grained distinctions among action types within a wide frontoparietal network.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.412","type":"journal-article","created":{"date-parts":[[2015,10,22]],"date-time":"2015-10-22T03:12:57Z","timestamp":1445483577000},"source":"Crossref","is-referenced-by-count":28,"title":["Probing the reaching\u2013grasping network in humans through multivoxel pattern decoding"],"prefix":"10.1002","volume":"5","author":[{"given":"Maria Grazia","family":"Di Bono","sequence":"first","affiliation":[{"name":"Department of General Psychology University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Begliomini","sequence":"additional","affiliation":[{"name":"Department of General Psychology University of Padova Padova Italy"},{"name":"Cognitive Neuroscience Center University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Castiello","sequence":"additional","affiliation":[{"name":"Department of General Psychology University of Padova Padova Italy"},{"name":"Cognitive Neuroscience Center University of Padova Padova Italy"},{"name":"Centro Interdisciplinare Beniamino Segre Accademia dei Lincei Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Zorzi","sequence":"additional","affiliation":[{"name":"Department of General Psychology University of Padova Padova Italy"},{"name":"Cognitive Neuroscience Center University of Padova Padova Italy"},{"name":"IRCCS San Camillo Hospital Venice\u2010Lido Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S1052-5149(25)00698-7","article-title":"Advances in cytoarchitectonic mapping of the human cerebral cortex","volume":"11","author":"Amunts K.","year":"2001","journal-title":"Neuroimaging Clin. 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