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This technique made it possible to assess changes in metabolic activity in clinical applications, such as the study of severe brain injury and disorders of consciousness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We assessed the possibility of creating functional <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> activity maps, which could estimate the relative levels of activity in <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> cerebral metabolic maps. If no metabolic absolute measures can be extracted, our approach may still be of clinical use in centers without access to <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>. It also overcomes the problem of recognizing individual networks of independent component selection in functional magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content>) resting state analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We extracted resting state <jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content> functional connectivity maps using independent component analysis and combined only components of neuronal origin. To assess neuronality of components a classification based on support vector machine (<jats:styled-content style=\"fixed-case\">SVM<\/jats:styled-content>) was used. We compared the generated maps with the <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> maps in 16 healthy controls, 11 vegetative state\/unresponsive wakefulness syndrome patients and four locked\u2010in patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results show a significant similarity with \u03c1\u00a0=\u00a00.75\u00a0\u00b1\u00a00.05 for healthy controls and \u03c1\u00a0=\u00a00.58\u00a0\u00b1\u00a00.09 for vegetative state\/unresponsive wakefulness syndrome patients between the <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> and the <jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content> based maps. <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> fMRI<\/jats:styled-content> neuronal maps, and the conjunction analysis show decreases in frontoparietal and medial regions in vegetative patients with respect to controls. Subsequent analysis in locked\u2010in syndrome patients produced also consistent maps with healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The constructed resting state <jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content> functional connectivity map points toward the possibility for <jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content> resting state to estimate relative levels of activity in a metabolic map.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.424","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T07:24:51Z","timestamp":1451373891000},"source":"Crossref","is-referenced-by-count":42,"title":["Correlation between resting state <scp>fMRI<\/scp> total neuronal activity and <scp>PET<\/scp> metabolism in healthy controls and patients with disorders of consciousness"],"prefix":"10.1002","volume":"6","author":[{"given":"Andrea","family":"Soddu","sequence":"first","affiliation":[{"name":"Department of Physics &amp; Astronomy, Brain and Mind Institute Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Computer Science Universidad Central de Colombia Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizette","family":"Heine","sequence":"additional","affiliation":[{"name":"GIGA\u2010Research &amp; Cyclotron Research Centre University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Di Perri","sequence":"additional","affiliation":[{"name":"GIGA\u2010Research &amp; Cyclotron Research Centre University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Ali","family":"Bahri","sequence":"additional","affiliation":[{"name":"GIGA\u2010Research &amp; Cyclotron Research Centre University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning U.","family":"Voss","sequence":"additional","affiliation":[{"name":"Department of Radiology Weill Cornell Medical College New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Aur\u00e9lie","family":"Bruno","sequence":"additional","affiliation":[{"name":"GIGA\u2010Research &amp; Cyclotron Research Centre University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Vanhaudenhuyse","sequence":"additional","affiliation":[{"name":"Department of Algology and Palliative Care University Hospital of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Phillips","sequence":"additional","affiliation":[{"name":"GIGA\u2010Research &amp; Cyclotron Research Centre University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athena","family":"Demertzi","sequence":"additional","affiliation":[{"name":"GIGA\u2010Research &amp; Cyclotron Research Centre University of Li\u00e8ge Li\u00e8ge Belgium"},{"name":"Brain and Spine Institute Institut du Cerveau et de la Moelle \u00e9pini\u00e8re (ICM) H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Chatelle","sequence":"additional","affiliation":[{"name":"GIGA\u2010Research &amp; Cyclotron Research Centre University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Schrouff","sequence":"additional","affiliation":[{"name":"GIGA\u2010Research &amp; Cyclotron Research Centre University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurore","family":"Thibaut","sequence":"additional","affiliation":[{"name":"GIGA\u2010Research &amp; Cyclotron Research Centre University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Charland\u2010Verville","sequence":"additional","affiliation":[{"name":"GIGA\u2010Research &amp; Cyclotron Research Centre University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Noirhomme","sequence":"additional","affiliation":[{"name":"GIGA\u2010Research &amp; Cyclotron Research Centre University of Li\u00e8ge Li\u00e8ge Belgium"},{"name":"Brain Innovation B.V. 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