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However, the exact neurophysiological profile within the somatosensory system, including primary somatosensory cortex (<jats:styled-content style=\"fixed-case\">SI<\/jats:styled-content>), contralateral (<jats:styled-content style=\"fixed-case\">SII<\/jats:styled-content>c), and ipsilateral (<jats:styled-content style=\"fixed-case\">SII<\/jats:styled-content>i) secondary somatosensory areas remains less understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study investigated the neuromagnetic cortical activities of median nerve stimulation in 10 patients with <jats:styled-content style=\"fixed-case\">WC<\/jats:styled-content> and 10 healthy controls (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>). To comprehensively explore all the aspects of somatosensory functioning, we analyzed our data with the minimum norm estimate (<jats:styled-content style=\"fixed-case\">MNE<\/jats:styled-content>), the time\u2010frequency approach with evoked and induced activities, and functional connectivity between <jats:styled-content style=\"fixed-case\">SI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SII<\/jats:styled-content>c (<jats:styled-content style=\"fixed-case\">SI<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">SII<\/jats:styled-content>c), <jats:styled-content style=\"fixed-case\">SI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SII<\/jats:styled-content>i (<jats:styled-content style=\"fixed-case\">SI<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">SII<\/jats:styled-content>i), and <jats:styled-content style=\"fixed-case\">SII<\/jats:styled-content>c and <jats:styled-content style=\"fixed-case\">SII<\/jats:styled-content>i (<jats:styled-content style=\"fixed-case\">SII<\/jats:styled-content>c\u2013<jats:styled-content style=\"fixed-case\">SII<\/jats:styled-content>i) from theta to gamma oscillations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant between\u2010group differences were found in the <jats:styled-content style=\"fixed-case\">MNE<\/jats:styled-content> cortical amplitudes of <jats:styled-content style=\"fixed-case\">SI<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> SII<\/jats:styled-content>c, and <jats:styled-content style=\"fixed-case\">SII<\/jats:styled-content>i. Power strengths of evoked gamma oscillation and induced beta synchronization were also equivalent between <jats:styled-content style=\"fixed-case\">WC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> groups. However, we found significantly reduced theta coherence of <jats:styled-content style=\"fixed-case\">SI<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">SII<\/jats:styled-content>i, alpha coherence of <jats:styled-content style=\"fixed-case\">SI<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">SII<\/jats:styled-content>i and <jats:styled-content style=\"fixed-case\">SII<\/jats:styled-content>c\u2013<jats:styled-content style=\"fixed-case\">SII<\/jats:styled-content>i, as well as beta coherence of <jats:styled-content style=\"fixed-case\">SII<\/jats:styled-content>c\u2013<jats:styled-content style=\"fixed-case\">SII<\/jats:styled-content>i in patients with <jats:styled-content style=\"fixed-case\">WC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest the involvement of somatosensory abnormalities, primarily with the form of functional connectivity, in patients with <jats:styled-content style=\"fixed-case\">WC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.433","type":"journal-article","created":{"date-parts":[[2016,1,26]],"date-time":"2016-01-26T08:56:39Z","timestamp":1453798599000},"source":"Crossref","is-referenced-by-count":18,"title":["Reduced functional connectivity of somatosensory network in writer's cramp patients"],"prefix":"10.1002","volume":"6","author":[{"given":"Chia\u2010Hsiung","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Occupational Therapy Graduate Institute of Behavioral Sciences Chang Gung University Taoyuan Taiwan"},{"name":"Healthy Aging Research Center Chang Gung University Taoyuan Taiwan"},{"name":"Department of Psychiatry Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Jhan","family":"Tseng","sequence":"additional","affiliation":[{"name":"Institute of Physiology National Yang\u2010Ming University Taipei 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