{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:22:09Z","timestamp":1780568529268,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,16]],"date-time":"2016-02-16T00:00:00Z","timestamp":1455580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study evaluated functional outcomes and safety after endoscopic and open bilateral carpal tunnel syndrome release in opposite hands of the same patients through a meta\u2010analysis of randomized controlled trial data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Randomized controlled trials involving both\u00a0methods in opposite hands of patients with bilateral carpal tunnel syndrome were identified via a systematic review of <jats:styled-content style=\"fixed-case\">PUBMED<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Relative risks (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>s) and 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s) from five randomized controlled trials involving 142 patients with bilateral carpal tunnel syndrome were calculated using fixed\u2010 or random\u2010effect methods, with a length of follow\u2010up from 24 to 52\u00a0weeks after surgery. Compared with open release, endoscopic carpal tunnel release was associated with significantly better Boston Carpal Tunnel Questionnaire functional status scores (mean difference [<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>]\u00a0=\u00a00.13, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] [0.02\u00a0\u2013\u00a00.25]; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02), but not symptom severity scores (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\u00a0=\u00a00.06, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> [\u22120.15 to 0.04]; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.25). Endoscopic release required a longer operative time, but the procedures did not differ significantly in visual analog scale pain scores (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\u00a0=\u00a00.02, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> [\u22120.08 to 0.11]; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.75), handgrip strength (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\u00a0=\u00a00.17, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> [\u22122.03 to 2.37]; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.88), digital sensibility static two\u2010point discrimination (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\u00a0=\u00a00.34, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> [\u22120.03 to 0.70]; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.07), or complication rates (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\u00a0=\u00a00.01, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> [\u22120.02 to 0.05], <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.47).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>From intraindividual evidence, endoscopic release promoted better recovery of daily life functions than open release, but required a longer operative time. The procedures provided similar symptom relief and hand strength and sensibility recovery, and were safe for patients with carpal tunnel syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.439","type":"journal-article","created":{"date-parts":[[2016,2,16]],"date-time":"2016-02-16T08:51:21Z","timestamp":1455612681000},"source":"Crossref","is-referenced-by-count":23,"title":["Intraindividual comparison between open and endoscopic release in bilateral carpal tunnel syndrome: a meta\u2010analysis of randomized controlled trials"],"prefix":"10.1002","volume":"6","author":[{"given":"Kejia","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Hand Surgery Huashan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiansong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine Huashan Hospital Jing\u2010an Branch (Jing\u2010an District Central Hospital) Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hand Surgery Huashan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(09)91044-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2012.02.017"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2008.10.026"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181b77f2d"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsb.2003.09.001"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199309000-00002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2006.01.030"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-013-1898-z"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0749-8063(89)90085-6"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199809020-00026"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753193408090104"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.84B3.12224"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-7681(02)00395-9"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_6_16_1","unstructured":"Higgins J. 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