{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T22:43:57Z","timestamp":1776379437785,"version":"3.51.2"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T00:00:00Z","timestamp":1461283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30970991"],"award-info":[{"award-number":["30970991"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2016,6]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>The precise associations between stroke and carotid plaques and dyslipidemia are unclear. This population\u2010based study aimed to examine the relationship between carotid plaques and dyslipidemia in a high\u2010stroke\u2010risk population.<\/jats:p><\/jats:sec>Methods<\/jats:title>Ultrasonography of left and right carotid arteries was conducted in 22,222 participants in a second screening survey of individuals with high stroke risk. Subjects were divided into two groups according to the presence or absence of carotid plaques. Blood TC<\/jats:styled-content> (total cholesterol), TG<\/jats:styled-content> (total triglycerides), and LDL<\/jats:styled-content>\u2010C (low\u2010density lipoprotein cholesterol) levels were recorded.<\/jats:p><\/jats:sec>Results<\/jats:title>Multivariate logistic regression analysis, controlled for gender, age, education, geographic region, smoking, exercise, and overweight (Model 2), identified TG<\/jats:styled-content> as a predictor of carotid\u2010plaque risk (odds ratio [OR<\/jats:styled-content>]\u00a0=\u00a01.109, 95% confidence interval [CI<\/jats:styled-content>]: 1.038\u20131.185, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.002), and the association between carotid plaques and LDL<\/jats:styled-content>\u2010C (OR<\/jats:styled-content>\u00a0=\u00a00.967, 95%CI<\/jats:styled-content>: 0.949\u20130.994, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.019) was less significant, whereas there was no association between carotid plaques and TC<\/jats:styled-content> (OR<\/jats:styled-content>\u00a0=\u00a01.002, 95%CI<\/jats:styled-content>: 0.932\u20131.007, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.958). After additional adjustment for hypertension, diabetes, and atrial fibrillation (Model 3), TG<\/jats:styled-content> remained a risk factor for carotid plaques (OR<\/jats:styled-content>\u00a0=\u00a01.086, 95%CI<\/jats:styled-content>: 1.016\u20131.161, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.015), but no associations were observed between carotid plaques and LDL<\/jats:styled-content>\u2010C (OR<\/jats:styled-content>\u00a0=\u00a00.972, 95%CI<\/jats:styled-content>: 0.910\u20131.038, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.394) or TC<\/jats:styled-content> (OR<\/jats:styled-content>\u00a0=\u00a01.003, 95%CI<\/jats:styled-content>: 0.933\u20131.079, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.928). Only the association between TG<\/jats:styled-content> and carotid plaques (OR<\/jats:styled-content>\u00a0=\u00a01.084, 95%CI<\/jats:styled-content>: 1.014\u20131.159, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.017) was independent of all covariates (covariates in Model 3 plus history of stroke or transient ischemic attack, and stroke family history) in Model 4.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>These findings indicate that TG<\/jats:styled-content> was an independent risk factor for carotid plaques in high\u2010risk population for stroke, whereas LDL<\/jats:styled-content>\u2010C and TC<\/jats:styled-content> were not associated with the appearance of carotid plaques independently.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.473","type":"journal-article","created":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T22:23:20Z","timestamp":1461363800000},"source":"Crossref","is-referenced-by-count":23,"title":["Relationship between dyslipidemia and carotid plaques in a\u00a0high\u2010stroke\u2010risk population in Shandong Province, China"],"prefix":"10.1002","volume":"6","author":[{"given":"Te","family":"Mi","sequence":"first","affiliation":[{"name":"Neurology Department Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shangwen","family":"Sun","sequence":"additional","affiliation":[{"name":"Cardio\u2010Cerebrovascular Control and Research Center Institute of Basic Medicine Shandong Academy of Medical Sciences Jinan Shandong 250062 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Neurology Department Weifang Chinese Medicine Hospital Weifang Shandong 261041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaser","family":"Carora","sequence":"additional","affiliation":[{"name":"Neurosurgery Department Wayne State University School of Medicine Detroit Michigan 48201 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifeng","family":"Du","sequence":"additional","affiliation":[{"name":"Neurology Department Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shougang","family":"Guo","sequence":"additional","affiliation":[{"name":"Neurology Department Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingfeng","family":"Cao","sequence":"additional","affiliation":[{"name":"Medical Department Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Medical Department Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Neurology Department Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinjian","family":"Sun","sequence":"additional","affiliation":[{"name":"Neurology Department Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Neurology Department Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanqiang","family":"Qu","sequence":"additional","affiliation":[{"name":"Neurology Department Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.37757\/MR2011V13.N4.6","article-title":"Acute myocardial infarction incidence, mortality and case fatality in Santa Clara, Cuba, 2007\u20132008","volume":"13","author":"Berm\u00fadez R.","year":"2011","journal-title":"MEDICC Rev."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arteri.2014.09.005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328352aba6"},{"key":"e_1_2_7_5_1","first-page":"128311288","article-title":"Carotid intima\u2010media thickness and plaque occurrence in predicting stable angiographic coronary artery disease","volume":"8","author":"Chang C.\u2010C.","year":"2013","journal-title":"Clin. Interv. Aging"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.01.013"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.11.025"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4943(05)80047-0"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-9-55"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.21.1.148"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000058157.69113.F6"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.08.042"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000018650.58984.75"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.05.011"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(02)00134-9"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2009.39.8.317"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7404.1423"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-010-0117-4"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.1.88"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-012-0240-y"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.587006"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.3.326"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410250410"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.11.073"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000321506"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319711435935"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074634"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.10.012"},{"key":"e_1_2_7_29_1","first-page":"1069","article-title":"The prevalence and onset of age of stoke in Chinese adults","volume":"43","author":"Zhai Y.","year":"2009","journal-title":"Chin. J. Prevent. Med."}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbrb3.473","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.473","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.473","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T08:57:57Z","timestamp":1696582677000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,22]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1002\/brb3.473"],"URL":"https:\/\/doi.org\/10.1002\/brb3.473","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,22]]},"article-number":"e00473"}}