{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:17:57Z","timestamp":1780543077535,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T00:00:00Z","timestamp":1463097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST103\u20102314\u2010B\u2010037\u2010004\u2010MY3"],"award-info":[{"award-number":["MOST103\u20102314\u2010B\u2010037\u2010004\u2010MY3"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","award":["KMUH101\u20101R44"],"award-info":[{"award-number":["KMUH101\u20101R44"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","award":["KMUH103\u20103R68"],"award-info":[{"award-number":["KMUH103\u20103R68"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Although statin therapy is beneficial to patients with ischemic stroke, statin use, and intracerebral hemorrhage (<jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>) remain a concern. <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> survivors commonly have comorbid cardiovascular risk factors that would otherwise warrant cholesterol\u2010lowering medication, thus emphasizing the importance of assessing the characteristics of statin therapy in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a cohort study by using 10\u00a0years of data collected from the National Health Insurance Research Database in Taiwan. We enrolled 726 patients admitted for newly diagnosed <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> from January 1, 2001 to December 31, 2010. The patients were categorized into high\u2010 (92), moderate\u2010 (545), and low\u2010intensity (89) statin groups, and into hydrophilic (295) and lipophilic (431) statin groups. The composite outcomes included all\u2010cause mortality, recurrent <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>, ischemic stroke, transient ischemic attack, and acute coronary events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients in the low\u2010intensity group did not differ significantly from the patients in the high\u2010intensity group in risk of all\u2010cause mortality (adjusted hazard ratio [<jats:styled-content style=\"fixed-case\">aHR<\/jats:styled-content>]\u00a0=\u00a00.65, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]\u00a0=\u00a00.28\u20131.55) and recurrent <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">aHR<\/jats:styled-content>\u00a0=\u00a00.66, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a00.30\u20131.44). In contrast, the patients in the hydrophilic group had a significantly lower risk of recurrent <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> than did those in the lipophilic group (<jats:styled-content style=\"fixed-case\">aHR<\/jats:styled-content>\u00a0=\u00a00.69, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a00.48\u20130.99). We determined no significant differences in other composite endpoints between hydrophilic and lipophilic statin use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hydrophilic statin therapy is associated with a reduced risk of recurrent <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> in post\u2010<jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> patients. The intensity of statin use had no significant effect on recurrent <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> or other components of the composite outcome. Additional studies are required to clarify the biological mechanisms underlying these observations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.487","type":"journal-article","created":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T13:42:32Z","timestamp":1463146952000},"source":"Crossref","is-referenced-by-count":33,"title":["Statin use after intracerebral hemorrhage: a 10\u2010year nationwide cohort study"],"prefix":"10.1002","volume":"6","author":[{"given":"Shu\u2010Yu","family":"Tai","sequence":"first","affiliation":[{"name":"Department of Family Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Family Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Family Medicine Kaohsiung Municipal Ta\u2010Tung Hospital Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng\u2010Cheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology Kaohsiung Medical University Hospital Kaohsiung Taiwan"},{"name":"Department of Neurology Pingtung Hospital Ministry of Health and Welfare Pingtung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung\u2010Yin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chai\u2010Jan","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Family Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Family Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Family Medicine Kaohsiung Municipal Hsiao\u2010Kang Hospital Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Tsang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Family Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Public Health Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Center of Environmental and Occupational Medicine Kaohsiung Municipal Hsiao\u2010Kang Hospital Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Yu","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Otorhinolaryngology Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Otorhinolaryngology Kaohsiung Municipal Hsiao\u2010Kang Hospital Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000236627.07927.7c"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70058-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061894"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12539"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182194be9"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.000916"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12649"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.645978"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02747.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.2124"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200767001-00006"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.122"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.000915"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000135225.80898.1c"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000296277.63350.77"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02838.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.228"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.23.9.1237"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-0956-4_66"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/157016111106140128113121"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12273"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.546259"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-013-0464-z"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2008.01891.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.655894"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.532473"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.001829"},{"key":"e_1_2_8_29_1","unstructured":"National Health Insurance Research Database NHRI.2000. Available fromhttp:\/\/nhird.nhri.org.tw\/en\/index.html. [10 May 2014]."},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12274"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200767150-00001"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100051453"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2003.10.033"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.000001"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.002751"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600800905"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.11.002"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200418030-00003"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/hq1101.098486"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.13.1.62"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-012-0431-0"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000144282.42222.DA"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01882.x"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000346744.56398.e5"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000194267.09060.77"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2011.00584.x"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta11140"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.06.015"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.4236\/jbbs.2013.31010"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.4236\/wjns.2013.32010"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.502807"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbrb3.487","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.487","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.487","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.487","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T01:00:58Z","timestamp":1696554058000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,13]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1002\/brb3.487"],"URL":"https:\/\/doi.org\/10.1002\/brb3.487","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,13]]},"article-number":"e00487"}}