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Maintenance of motor function is dependent on functional connectivity of these premotor, motor, and dorsolateral frontostriatal circuits, and structural integrity of the striatum itself. We aimed to investigate whether size and shape of the striatum as a measure of frontostriatal circuit structural integrity was correlated with functional frontostriatal electrophysiological neural premotor processing (contingent negative variation, CNV), to better understand motoric structure\u2013function relationships in early <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) scans and electrophysiological (<jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>) measures of premotor processing were obtained from a combined <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> group (12 presymptomatic, 7 symptomatic). Manual segmentation of caudate and putamen was conducted with subsequent shape analysis. Separate correlational analyses (volume and shape) included covariates of age, gender, intracranial volume, and time between <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Right caudate volume correlated with early <jats:styled-content style=\"fixed-case\">CNV<\/jats:styled-content> latency over frontocentral regions and late <jats:styled-content style=\"fixed-case\">CNV<\/jats:styled-content> frontally, whereas right caudate shape correlated with early <jats:styled-content style=\"fixed-case\">CNV<\/jats:styled-content> latency centrally. Left caudate volume correlated with early <jats:styled-content style=\"fixed-case\">CNV<\/jats:styled-content> latency over centroparietal regions and late <jats:styled-content style=\"fixed-case\">CNV<\/jats:styled-content> frontally. Right and left putamen volumes correlated with early <jats:styled-content style=\"fixed-case\">CNV<\/jats:styled-content> latency frontally, and right and left putamen shape\/volume correlated with parietal <jats:styled-content style=\"fixed-case\">CNV<\/jats:styled-content> slope.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Timing (latency) and pattern (slope) of frontostriatal circuit\u2010mediated premotor functional activation across scalp regions were correlated with abnormalities in structural integrity of the key frontostriatal circuit component, the striatum (size and shape). This was accompanied by normal reaction times, suggesting it may be undetected in regular tasks due to preserved motor \u201cperformance.\u201d Such differences in functional activation may reflect atrophy\u2010based frontostriatal circuitry despecialization and\/or compensatory recruitment of additional brain regions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.511","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T02:12:39Z","timestamp":1469671959000},"source":"Crossref","is-referenced-by-count":7,"title":["Striatal morphology correlates with frontostriatal electrophysiological motor processing in Huntington's disease: an IMAGE\u2010HD study"],"prefix":"10.1002","volume":"6","author":[{"given":"Lauren M.","family":"Turner","sequence":"first","affiliation":[{"name":"Research School of Psychology College of Medicine, Biology, &amp; Environment Australian National University Canberra Australian Capital Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Jakabek","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine University of Wollongong Wollongong New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona A.","family":"Wilkes","sequence":"additional","affiliation":[{"name":"Academic Unit of Psychiatry and Addiction Medicine Australian National University Medical School Canberra Hospital Canberra Australian Capital Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney J.","family":"Croft","sequence":"additional","affiliation":[{"name":"School of Psychology &amp; Illawarra Health &amp; Medical Research Institute University of Wollongong Wollongong New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Churchyard","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences Faculty of Medicine, Nursing and Health Sciences Monash University Monash Victoria Australia"},{"name":"Calvary Health Care Bethlehem Hospital Caulfield Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Walterfang","sequence":"additional","affiliation":[{"name":"Neuropsychiatry Unit Royal Melbourne Hospital, and Melbourne Neuropsychiatry Centre University of Melbourne Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Velakoulis","sequence":"additional","affiliation":[{"name":"Neuropsychiatry Unit Royal Melbourne Hospital, and Melbourne Neuropsychiatry Centre University of Melbourne Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey C. 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