{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:20:38Z","timestamp":1790806838217,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T00:00:00Z","timestamp":1470096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Exc 257"],"award-info":[{"award-number":["Exc 257"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Emerging evidence suggests that fatigue in myasthenia gravis (<jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>) is a relevant problem that negatively impacts activities of daily living (<jats:styled-content style=\"fixed-case\">ADL<\/jats:styled-content>). The relationship between fatigue and quality of life (QoL) has never been systematically explored in <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> patients. The study aimed to assess the prevalence of fatigue and its relation to <jats:styled-content style=\"fixed-case\">ADL<\/jats:styled-content> and QoL as well as to identify factors associated with fatigue in <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>This was a cross\u2010sectional observational study in patients with confirmed diagnosis of <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> independent of disease severity. Prevalence of fatigue was assessed using the Chalder Fatigue Scale (<jats:styled-content style=\"fixed-case\">CFQ<\/jats:styled-content>). Impact of fatigue on <jats:styled-content style=\"fixed-case\">ADL<\/jats:styled-content> and QoL was assessed by the <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> activities of daily living profile (<jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ADL<\/jats:styled-content>) and the <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>\u2010specific quality\u2010of\u2010life instrument (<jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>\u2010QoL), respectively. Association of fatigue with sociodemographics, clinical characteristics of <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>, and comorbidities including mood and anxiety disorders as well as sleep disorders was investigated using multivariable logistic regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 200 <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> patients were included. The observed rate of fatigue was 56.1%, of those 70.4% fulfilled the criteria of chronic fatigue (<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>) with a duration of \u22656\u00a0months. Relevant fatigue was strongly associated to <jats:styled-content style=\"fixed-case\">ADL<\/jats:styled-content> and QoL. Factors associated with relevant fatigue were disease severity and depressive state. Furthermore, positive muscle\u2010specific tyrosine kinase (Mu<jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content>) antibody status showed a strong association with relevant fatigue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> patients have a high prevalence of fatigue which negatively impacts <jats:styled-content style=\"fixed-case\">ADL<\/jats:styled-content> and QoL. <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>\u2010specific clinical characteristics are related to fatigue and might help to identify <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> patients at risk for fatigue.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.538","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T03:17:35Z","timestamp":1470194255000},"source":"Crossref","is-referenced-by-count":94,"title":["Fatigue in myasthenia 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