{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T04:49:56Z","timestamp":1778734196222,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,10,3]],"date-time":"2016-10-03T00:00:00Z","timestamp":1475452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002960","name":"V\u00e4sterbotten L\u00e4ns Landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002960","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Disturbed phosphate homeostasis in early Parkinson\u2032s disease (PD) may originate from a stress\u2010related condition and nutritional status among other risk factors, age, and gender.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Risk of malnutrition using Mini\u2010nutritional assessment (MNA score) and plasma levels of protein markers and daytime cortisol at the time of diagnosis in PD (<jats:italic>n<\/jats:italic>\u00a0=\u00a075) were compared with a control group (<jats:italic>n<\/jats:italic>\u00a0=\u00a024). Cognition was assessed using the Mini\u2010Mental State Examination (MMSE score) and motor function using Unified Parkinson\u2032s Disease Rating Scale (UPDRS\u2010part III scale).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients with PD had significantly lower MNA score than controls which correlated with plasma phosphate levels. The logistic regression revealed that increasing MNA protected from low plasma phosphate, final score (OR\u00a0=\u00a00.399; 95% CI\u00a0=\u00a00.196\u20130.816; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.012) and total score (OR\u00a0=\u00a00.656; 95% CI\u00a0=\u00a00.422\u20131.018; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.060). Phosphate correlated with albumin (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.315; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.006), transferrin (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.331; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.004) and cortisol (<jats:italic>r<\/jats:italic>\u00a0=\u00a0<jats:italic>\u2212<\/jats:italic>0.355; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.002) confirmed by logistic regressions. Increasing albumin protects from low phosphate after adjusting in logistic regression (OR\u00a0=\u00a00.806; 95% CI\u00a0=\u00a00.682\u20130.952; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.011) and after including variables from Table 1 in backwards elimination, final step (OR\u00a0=\u00a00.800; 95% CI\u00a0=\u00a00.660\u20130.969; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.022). MNA total score and cortisol correlated inversely, confirmed in logistic regression for MNA total score (OR\u00a0=\u00a00.786; 95% CI\u00a0=\u00a00.627\u20130.985; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.037) and for MNA initial score (OR\u00a0=\u00a00.650; 95% CI\u00a0=\u00a00.453\u20130.930; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.020).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study highlights the importance of phosphate for optimal nutritional status by association with MNA score and albumin in plasma. An inverse relationship between phosphate and cortisol indicate, in addition, that low phosphate levels may affect cognition and motor function in PD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.556","type":"journal-article","created":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T15:45:08Z","timestamp":1475855108000},"source":"Crossref","is-referenced-by-count":21,"title":["Covariation between plasma phosphate and daytime cortisol in early Parkinson's disease"],"prefix":"10.1002","volume":"6","author":[{"given":"Lena","family":"H\u00e5glin","sequence":"first","affiliation":[{"name":"Department of Public Health and Clinical Medicine, Family Medicine Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lennart","family":"B\u00e4ckman","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine, Family Medicine Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-013-2970-4"},{"key":"e_1_2_8_3_1","first-page":"2133","article-title":"Major depression in late life is associated with both hypo\u2010 and hypercortisolemia","volume":"27","author":"Bremmer M. 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