{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:59:31Z","timestamp":1788911971382,"version":"build-2803163510"},"reference-count":63,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T00:00:00Z","timestamp":1475020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["0541000"],"award-info":[{"award-number":["0541000"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Recent evidence suggests that attention deficit hyperactivity disorder (<jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content>) is associated with a range of brain functional connectivity abnormalities, with one of the most prominent being reduced inhibition of the default mode network (<jats:styled-content style=\"fixed-case\">DMN<\/jats:styled-content>) while performing a cognitive task. In this study, we examine the effects of a methylphenidate dose on brain functional connectivity in boys diagnosed with <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content> while they performed a cognitive task.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Brain functional connectivity was estimated using steady\u2010state visual evoked potential partial coherence before and 90\u00a0min after the administration of a methylphenidate dose to 42 stimulant drug\u2010na\u00efve boys newly diagnosed with <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content> while they performed the A\u2010X version of the continuous performance task (<jats:styled-content style=\"fixed-case\">CPT<\/jats:styled-content> A\u2010X).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Methylphenidate robustly reversed the transient functional connectivity increase in the A\u2010X interval seen premedication to a postmedication decrease during this interval. In addition, methylphenidate\u2010induced reductions in individual reaction time were correlated with corresponding reductions in functional connectivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest that methylphenidate suppresses the increased functional connectivity observed in <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content> and that such suppression is associated with improved performance. Our findings support the suggestion that the increased functional connectivity we have observed in <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content> is associated with abnormal <jats:styled-content style=\"fixed-case\">DMN<\/jats:styled-content> activity. In addition, we comment on the significance of specific frequency channels mediating top\u2010down communication within the cortex and the extent to which our findings are selectively sensitive to top\u2010down intracortical communication.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.582","type":"journal-article","created":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T08:58:58Z","timestamp":1475053138000},"source":"Crossref","is-referenced-by-count":30,"title":["Dopaminergic modulation of default mode network brain functional connectivity in attention deficit hyperactivity disorder"],"prefix":"10.1002","volume":"6","author":[{"given":"Richard B.","family":"Silberstein","sequence":"first","affiliation":[{"name":"Centre for Human Psychopharmacology Swinburne University  Hawthorn Vic. Australia"},{"name":"Neuro\u2010Insight Pty Ltd  Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Pipingas","sequence":"additional","affiliation":[{"name":"Centre for Human Psychopharmacology Swinburne University  Hawthorn Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maree","family":"Farrow","sequence":"additional","affiliation":[{"name":"Wicking Dementia Research and Education Centre University of Tasmania  Hobart Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Levy","sequence":"additional","affiliation":[{"name":"Head Child and Family East Prince of Wales Hospital and School of Psychiatry University of New South Wales  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Con K.","family":"Stough","sequence":"additional","affiliation":[{"name":"Centre for Human Psychopharmacology Swinburne University  Hawthorn Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.12.018"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300839"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2010.04.004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2014.08.010"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-199401020-00002"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1440.011"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1011284108"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.01.034"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq010"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.06.025"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2006.01.011"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.185"},{"key":"e_1_2_6_14_1","first-page":"993","article-title":"Association of Attention\u2010Deficit Disorder and the Dopamine Transporter Gene","volume":"56","author":"Cook E. H.","year":"1995","journal-title":"American Journal of Human Genetics"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2014.02.001"},{"key":"e_1_2_6_16_1","first-page":"1038","article-title":"Toward systems neuroscience of ADHD: A meta\u2010analysis of 55 fMRI studies","volume":"169","author":"Cortese S.","year":"2012","journal-title":"Perspectives"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.104"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.02.036"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.02.070"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2014.12.006"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/1.1.1"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.120054"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.09.034"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2011.08.002"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.01.030"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsu001"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl147"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000290"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00401-4"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.01.057"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.08.008"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(83)90071-8"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.06.044"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-005-0144-y"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199706000-00009"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2010.02333.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.03.022"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23458"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1131295"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.1981.tb01841.x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026683200895"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.08050724"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.03.048"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.676"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2009.08.013"},{"key":"e_1_2_6_46_1","first-page":"36","article-title":"Proceedings: CNS function and response to methylphenidate in hyperactive children","volume":"10","author":"Satterfield J. H.","year":"1974","journal-title":"Psychopharmacology bulletin"},{"key":"e_1_2_6_47_1","first-page":"272","article-title":"Steady State Visually Evoked Potentials, Brain Resonances and Cognitive Processes","author":"Silberstein R. B","year":"1995","journal-title":"Neocortical Dynamics and Human EEG Rhythms"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(06)59005-3"},{"key":"e_1_2_6_49_1","first-page":"379","article-title":"Steady\u2010state visually evoked potential topography dynamics and cognition","author":"Silberstein R. B.","year":"1996","journal-title":"Recent advances in event\u2010related brain potential research"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200301200-00013"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.55.12.1105"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(99)00324-7"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8760(01)00167-2"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.583"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:BRAT.0000032860.04812.b1"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2007.02.005"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2011.07.001"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006102"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.06.011"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.26.14748"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1727"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.02.006"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf156"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.11.011"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbrb3.582","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbrb3.582","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.582","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.582","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.582","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T09:20:57Z","timestamp":1696584057000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,28]]},"references-count":63,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1002\/brb3.582"],"URL":"https:\/\/doi.org\/10.1002\/brb3.582","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,28]]},"article-number":"e00582"}}