{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:53:28Z","timestamp":1762955608240,"version":"3.41.2"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T00:00:00Z","timestamp":1477008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["1563000227"],"award-info":[{"award-number":["1563000227"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271327"],"award-info":[{"award-number":["81271327"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2017,1]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Previous studies have shown that serum uric acid (UA<\/jats:styled-content>) modulates outcomes of neurological diseases, although little is known about cerebrospinal fluid (CSF<\/jats:styled-content>) UA<\/jats:styled-content> levels in neuromyelitis optica spectrum disorders (NMOSD<\/jats:styled-content>s).<\/jats:p><\/jats:sec>Methods<\/jats:title>Cerebrospinal fluid and serum UA<\/jats:styled-content> levels were measured in samples from 68 patients, including NMOSD<\/jats:styled-content>s during relapse (n\u00a0<\/jats:italic>=\u00a038) and controls with noninflammatory and non\u2010neurodegenerative diseases (CTL<\/jats:styled-content>s, n\u00a0<\/jats:italic>=\u00a030). Correlation analysis was performed between CSF UA<\/jats:styled-content> and clinical characteristics, serum UA<\/jats:styled-content>, and blood\u2013brain barrier integrity in NMOSD<\/jats:styled-content>s.<\/jats:p><\/jats:sec>Results<\/jats:title>Cerebrospinal fluid UA<\/jats:styled-content> levels in NMOSD<\/jats:styled-content>s were significantly higher than in CTL<\/jats:styled-content>s (p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.002), while serum UA<\/jats:styled-content> differences between NMOSD<\/jats:styled-content>s and CTL<\/jats:styled-content>s were not statistically significant. In NMOSD<\/jats:styled-content>s, CSF UA<\/jats:styled-content> levels were significantly higher in patients with an impaired blood\u2013brain barrier than in patients with an intact one (p\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001), and significantly higher in longer disease duration than in shorter disease duration patients (p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.002). CSF UA<\/jats:styled-content> levels were also significantly higher in active patients upon MRI<\/jats:styled-content> than in inactive patients (p\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001), and significantly higher in patients with brain lesions than without brain lesions (p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.024). CSF UA<\/jats:styled-content> was significantly associated with the serum UA<\/jats:styled-content> levels (r\u00a0<\/jats:italic>=\u00a0.454, p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.002), disease duration (r\u00a0<\/jats:italic>=\u00a0.383, p<\/jats:italic>\u00a0=\u00a0.018), and blood\u2013brain barrier index (r\u00a0<\/jats:italic>=\u00a0.805, p\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001), but did not correlate with age, gender, annualized relapse rate, duration, or severity of NMOSD<\/jats:styled-content>. Multiple regression analysis demonstrated that CSF UA<\/jats:styled-content> was independent of the blood\u2013brain barrier index (\u03b2\u00a0=\u00a0.765, p\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001) and serum UA<\/jats:styled-content> levels (\u03b2\u00a0=\u00a0.01, p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.019) in NMOSD<\/jats:styled-content>s.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Cerebrospinal fluid UA<\/jats:styled-content> levels were elevated in NMOSD<\/jats:styled-content> patients during relapse, and were likely modified by serum UA<\/jats:styled-content> levels and blood\u2013brain barrier integrity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.584","type":"journal-article","created":{"date-parts":[[2016,10,22]],"date-time":"2016-10-22T04:29:43Z","timestamp":1477110583000},"source":"Crossref","is-referenced-by-count":14,"title":["Elevated cerebrospinal fluid uric acid during relapse of neuromyelitis optica spectrum disorders"],"prefix":"10.1002","volume":"7","author":[{"given":"Yaqing","family":"Shu","sequence":"first","affiliation":[{"name":"Department of Neurology The Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology The Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology The Fifth Affiliated Hospital of Sun Yat\u2010sen University Zhuhai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuge","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology The Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou 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