{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T19:51:50Z","timestamp":1783367510882,"version":"3.54.6"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T00:00:00Z","timestamp":1478131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["WT088134\/Z\/09\/A"],"award-info":[{"award-number":["WT088134\/Z\/09\/A"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In structural Magnetic Resonance Imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) of patients with a recent small subcortical infarct (<jats:styled-content style=\"fixed-case\">RSSI<\/jats:styled-content>) and small vessel disease (<jats:styled-content style=\"fixed-case\">SVD<\/jats:styled-content>) imaging markers coexist. However, their spatial distribution and prevalence with respect to the hemisphere of the <jats:styled-content style=\"fixed-case\">RSSI<\/jats:styled-content> remain unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>From brain <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> in 187 patients with an acute lacunar ischemic stroke clinical syndrome and a relevant diffusion weighted imaging (<jats:styled-content style=\"fixed-case\">DWI<\/jats:styled-content>)\u2010positive lesion, we semiautomatically extracted the <jats:styled-content style=\"fixed-case\">RSSI<\/jats:styled-content>, microbleeds, lacunes, old cortical infarcts, and white matter hyperintensities (<jats:styled-content style=\"fixed-case\">WMH<\/jats:styled-content>) using optimized thresholding in the relevant sequences, and rated the load of perivascular spaces. We registered all images to an age\u2010relevant brain template and calculated the probability distribution of all <jats:styled-content style=\"fixed-case\">SVD<\/jats:styled-content> markers mentioned for patients who had the <jats:styled-content style=\"fixed-case\">RSSI<\/jats:styled-content> in each hemisphere separately. We used the Wilcoxon and chi\u2010squared tests to compare the volumes and frequencies of occurrence, respectively, of the <jats:styled-content style=\"fixed-case\">SVD<\/jats:styled-content> markers between hemispheres throughout the sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010two percent patients (<jats:italic>n\u00a0<\/jats:italic>=\u00a097) had the <jats:styled-content style=\"fixed-case\">RSSI<\/jats:styled-content> in the left hemisphere, 42% (<jats:italic>n\u00a0<\/jats:italic>=\u00a078) in the right, 2.7% (<jats:italic>n\u00a0<\/jats:italic>=\u00a05) in both, and 3.7% (<jats:italic>n\u00a0<\/jats:italic>=\u00a07) in the cerebellum or brainstem. There was no significant difference in <jats:styled-content style=\"fixed-case\">RSSI<\/jats:styled-content> frequency between left and right hemispheres (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.10) in the sample. The median volume of the <jats:styled-content style=\"fixed-case\">RSSI<\/jats:styled-content> (expressed as a percentage of the total intracranial volume) was 0.05% (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\u00a0=\u00a00.06). There was no difference in median percent volume of the right <jats:styled-content style=\"fixed-case\">RSSI<\/jats:styled-content>s versus left (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.16). Neither was there a significant interhemispheric difference in the volume of any of the <jats:styled-content style=\"fixed-case\">SVD<\/jats:styled-content> markers regardless of the location of the <jats:styled-content style=\"fixed-case\">RSSI<\/jats:styled-content> and they were equally distributed in both hemispheres.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Assessment of <jats:styled-content style=\"fixed-case\">SVD<\/jats:styled-content> imaging markers in the contralateral hemisphere could be used as a proxy for the <jats:styled-content style=\"fixed-case\">SVD<\/jats:styled-content> load in the whole brain to avoid contamination by the <jats:styled-content style=\"fixed-case\">RSSI<\/jats:styled-content> of the measurements, especially of <jats:styled-content style=\"fixed-case\">WMH<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.595","type":"journal-article","created":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T09:29:18Z","timestamp":1478165358000},"source":"Crossref","is-referenced-by-count":9,"title":["Interhemispheric characterization of small vessel disease imaging markers after subcortical infarct"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2771-6546","authenticated-orcid":false,"given":"Maria del C.","family":"Vald\u00e9s Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Department of Neuroimaging Sciences Centre for Clinical Brain Sciences University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Qiu","sequence":"additional","affiliation":[{"name":"College of Medicine and Veterinary Medicine University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neuroimaging Sciences Centre for Clinical Brain Sciences University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart","family":"Wiseman","sequence":"additional","affiliation":[{"name":"Department of Neuroimaging Sciences Centre for Clinical Brain Sciences University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Sakka","sequence":"additional","affiliation":[{"name":"Department of Neuroimaging Sciences Centre for Clinical Brain Sciences University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy C.","family":"Maconick","sequence":"additional","affiliation":[{"name":"Buckinghamshire Healthcare NHS Trust  Buckinghamshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fergus","family":"Doubal","sequence":"additional","affiliation":[{"name":"Department of Neuroimaging Sciences Centre for Clinical Brain Sciences University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathie L. 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