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When linking sensory evidence with higher\u2010level expectations for action, the central nervous system (CNS<\/jats:styled-content>) in typically developing (TD<\/jats:styled-content>) individuals relies in part on distributed and interacting cortical regions to communicate neuronal signals flexibly across the brain. Increasing evidence suggests that the balance between levels of signal and noise during information processing may be disrupted in individuals with Autism Spectrum Disorders (ASD<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Participants with and without ASD<\/jats:styled-content> performed a visuospatial interference task while undergoing functional Magnetic Resonance Imaging (fMRI<\/jats:styled-content>). We empirically estimated parameters characterizing participants\u2019 latencies and their subtle fluctuations (noise accumulation) over the 16\u2010min scan. We modeled hemodynamic activation and used seed\u2010based analyses of neural coupling to study dysfunction in interference\u2010specific connectivity in a subset of ASD<\/jats:styled-content> participants who were nonparametrically matched to TD<\/jats:styled-content> participants on age, male\u2010to\u2010female ratio, and magnitude of movement during the scan.<\/jats:p><\/jats:sec>Results<\/jats:title>Stochastic patterns of response fluctuations reveal significantly higher noise\u2010to\u2010signal levels and a more random and noisy structure in ASD<\/jats:styled-content> versus TD<\/jats:styled-content> participants, and in particular ASD<\/jats:styled-content> adults who have the greatest clinical autistic deficits. While individuals with ASD<\/jats:styled-content> show an overall weaker modulation of interference\u2010specific functional connectivity relative to TD<\/jats:styled-content> individuals, in particular between the seeds of Anterior Cingulate Cortex (ACC<\/jats:styled-content>) and Inferior Parietal Sulcus (IPS<\/jats:styled-content>) and the rest of the brain, we found that in ASD<\/jats:styled-content>, higher uncertainty during the task is linked to increased interference\u2010specific coupling between bilateral anterior insula and prefrontal cortex.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Subtle and informative differences in the structure of experiencing information exist between ASD<\/jats:styled-content> and TD<\/jats:styled-content> individuals. Our findings reveal in ASD<\/jats:styled-content> an atypical capacity to apply previously perceived information in a manner optimal for adaptive functioning, plausibly revealing suboptimal message\u2010passing across the CNS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.596","type":"journal-article","created":{"date-parts":[[2016,12,25]],"date-time":"2016-12-25T05:12:43Z","timestamp":1482642763000},"source":"Crossref","is-referenced-by-count":14,"title":["Cortical interactions during the resolution of information processing demands in autism spectrum disorders"],"prefix":"10.1002","volume":"7","author":[{"given":"Kristina","family":"Denisova","sequence":"first","affiliation":[{"name":"Department of Psychiatry Center for Developmental Neuropsychiatry Columbia University College of Physicians and Surgeons New York NY USA"},{"name":"Division of Developmental Neuroscience New York State Psychiatric Institute New York NY USA"},{"name":"Sackler Institute for Developmental Psychobiology Columbia University College of Physicians and Surgeons New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guihu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Center for Developmental Neuropsychiatry Columbia University College of Physicians and Surgeons New York NY USA"},{"name":"School of Information Science and Engineering Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhishun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Center for Developmental Neuropsychiatry Columbia University College of Physicians and Surgeons New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Goh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Center for Developmental Neuropsychiatry Columbia University College of Physicians and Surgeons New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuankai","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Center for Developmental Neuropsychiatry Columbia University College of Physicians and Surgeons New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley S.","family":"Peterson","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles Keck School of Medicine of the University of Southern California Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,24]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"635","volume-title":"Human brain function","author":"Ashburner J.","year":"2004"},{"key":"e_1_2_8_3_1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"Association, A.P.","year":"2000"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005653411471"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-010-1157-x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3340-04.2004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.11.078"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2009.06.003"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.082"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579402002018"},{"key":"e_1_2_8_11_1","volume-title":"Social responsiveness scale (SRS)","author":"Constantino J. 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