{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:35:12Z","timestamp":1785285312721,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,31]],"date-time":"2016-10-31T00:00:00Z","timestamp":1477872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2017,1]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>Serum uric acid (UA<\/jats:styled-content>) levels are reported to be decreased in patients with Parkinson's disease (PD<\/jats:styled-content>) and multiple system atrophy (MSA<\/jats:styled-content>). However, clinical correlates of serum UA<\/jats:styled-content> levels are still unclear in PD<\/jats:styled-content>\u2010related disorders. We conducted a cross\u2010sectional study to evaluate the associations between serum UA<\/jats:styled-content> levels and disease duration, disease severity, and motor function among PD<\/jats:styled-content>, MSA<\/jats:styled-content>, and progressive supranuclear palsy (PSP<\/jats:styled-content>) patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 100 patients with PD<\/jats:styled-content>, 42 patients with MSA<\/jats:styled-content>, 30 patients with PSP<\/jats:styled-content>, and 100 controls were included in this study. Serum UA<\/jats:styled-content> levels were determined, and associations among serum UA<\/jats:styled-content> levels and disease duration, disease severity, and motor function in PD<\/jats:styled-content>, PSP<\/jats:styled-content>, and MSA<\/jats:styled-content> patients were evaluated.<\/jats:p><\/jats:sec>Results<\/jats:title>Serum UA<\/jats:styled-content> levels were significantly lower in male PD<\/jats:styled-content>, MSA<\/jats:styled-content>, and PSP<\/jats:styled-content> patients compared with the controls, but not in female patients. Serum UA<\/jats:styled-content> levels were negatively correlated with disease duration and severity in MSA<\/jats:styled-content> and PSP<\/jats:styled-content> patients, but no correlations were observed in PD<\/jats:styled-content> patients. The serum UA<\/jats:styled-content> levels were significantly decreased in the tauopathy group (PSP<\/jats:styled-content> patients) compared with the synucleinopathy group (PD<\/jats:styled-content> and MSA<\/jats:styled-content> patients) after adjusting for age, gender, and body mass index.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>We found decreased serum UA<\/jats:styled-content> levels in male patients with PD<\/jats:styled-content>\u2010related disorders (PD<\/jats:styled-content>, MSA<\/jats:styled-content>, and PSP<\/jats:styled-content>) compared with male controls, and significant correlations between serum UA<\/jats:styled-content> levels and disease severity in MSA<\/jats:styled-content> and PSP<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.598","type":"journal-article","created":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T03:33:01Z","timestamp":1477971181000},"source":"Crossref","is-referenced-by-count":35,"title":["Serum uric 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