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Neurological disorders are mostly associated with <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content> babies with an abnormally high cephalization index (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) and a brain sparing effect. However, a similar correlation has never been demonstrated in an animal model. The aim of this study was to determine the correlations between <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, functional deficits in learning and memory and alterations in synaptic proteins in a rat model of <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Utero\u2010placental insufficiency was induced by meso\u2010ovarian vessel cauterization (<jats:styled-content style=\"fixed-case\">CMO<\/jats:styled-content>) in pregnant rats at embryonic day 17 (E17). Learning performance in an aquatic learning test was evaluated 25\u00a0days after birth and during 10\u00a0days. Some synaptic proteins were analyzed (<jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content>95, Synaptophysin) by Western blot and immunohistochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Placental insufficiency in <jats:styled-content style=\"fixed-case\">CMO<\/jats:styled-content> pups was associated with spatial memory deficits, which are correlated with a <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> above the normal range. <jats:styled-content style=\"fixed-case\">CMO<\/jats:styled-content> pups presented altered levels of synaptic proteins <jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content>95 and synaptophysin in the hippocampus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of this study suggest that learning disabilities may be associated with altered development of excitatory neurotransmission and synaptic plasticity. Although interspecific differences in fetal response to placental insufficiency should be taken into account, the translation of these data to humans suggest that both <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content> babies and babies with a normal birth weight but with intrauterine Doppler alterations and abnormal <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> should be closely followed to detect neurodevelopmental alterations during the postnatal period.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.631","type":"journal-article","created":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T05:56:47Z","timestamp":1486447007000},"source":"Crossref","is-referenced-by-count":24,"title":["Learning and memory disabilities in <scp>IUGR<\/scp> babies: Functional and molecular analysis in a rat 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