{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:48:41Z","timestamp":1775695721800,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T00:00:00Z","timestamp":1489104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81072765"],"award-info":[{"award-number":["81072765"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81173237"],"award-info":[{"award-number":["81173237"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473640)"],"award-info":[{"award-number":["81473640)"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2017,4]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Discovery of specific antibodies against astrocytic water channel aquaporin\u20104 (AQP<\/jats:styled-content>4), which is produced by plasma cells, in the serum of neuromyelitis optica (NMO<\/jats:styled-content>) confirmed the pathogenic role of B cells in NMO<\/jats:styled-content>. C\u2010X\u2010C motif ligand 13 (CXCL<\/jats:styled-content>13) and B\u2010cell\u2010activating factor (BAFF<\/jats:styled-content>) are two crucial factors for antibody production. Relevant studies have focused on the acute phase of NMO<\/jats:styled-content>. However, CXCL<\/jats:styled-content>13 and BAFF<\/jats:styled-content> levels during remission, remain to be elucidated.<\/jats:p><\/jats:sec>Objective<\/jats:title>To evaluate serum levels of CXCL<\/jats:styled-content>13 and BAFF<\/jats:styled-content> in NMO<\/jats:styled-content> and multiple sclerosis (MS<\/jats:styled-content>) patients during remission and explore their correlation with immunosuppressive agents and clinical features in NMO<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Serum CXCL<\/jats:styled-content>13 and BAFF<\/jats:styled-content> were measured by enzyme\u2010linked immunosorbent assay (ELISA<\/jats:styled-content>) in NMO<\/jats:styled-content> patients, MS<\/jats:styled-content> patients, and controls.<\/jats:p><\/jats:sec>Results<\/jats:title>Serum CXCL<\/jats:styled-content>13 levels of NMO<\/jats:styled-content> patients (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>24) were significantly higher than those of controls (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>22) (p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.001), but CXCL<\/jats:styled-content>13 levels of MS<\/jats:styled-content> patients (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>20) and controls (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>22) did not differ significantly (p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.279). Although the three groups showed no differences in serum BAFF<\/jats:styled-content> levels, serum BAFF<\/jats:styled-content> levels of NMO<\/jats:styled-content> patients without immunosuppressive treatment (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>8) were significantly elevated compared with those of NMO<\/jats:styled-content> patients with immunosuppressive therapy (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>16) (p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.003) and controls (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>22) (p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.024). In NMO<\/jats:styled-content> patients, CXCL<\/jats:styled-content>13 levels were correlated with onset age (p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.026) and duration to the last relapse (p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.003).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>During remission, serum CXCL<\/jats:styled-content>13 and BAFF<\/jats:styled-content> levels have not decreased to normal in NMO<\/jats:styled-content> patients, and B\u2010cell\u2010related autoimmune response persists. Immunosuppressive therapy decreased serum BAFF<\/jats:styled-content> levels, but did not affect CXCL<\/jats:styled-content>13 expression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.648","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T15:38:25Z","timestamp":1489160305000},"source":"Crossref","is-referenced-by-count":10,"title":["Elevated C\u2010X\u2010C motif ligand 13 and B\u2010cell\u2010activating factor levels in neuromyelitis optica during remission"],"prefix":"10.1002","volume":"7","author":[{"given":"Su","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine Beijing Tiantan Hospital Capital Medical University Beijing China"},{"name":"Department of Oncology Qingdao Hiser Medical Group Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine Beijing Tiantan Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianglong","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine Beijing Tiantan Hospital Capital Medical University Beijing China"},{"name":"Department of Traditional Chinese Medicine Miyun Xitiangezhuang Town Community Health Service Center Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongchao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Traumatic Orthopedics Qingdao Hiser Medical Group Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9010-5628","authenticated-orcid":false,"given":"Yongping","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine Beijing Tiantan Hospital Capital Medical University Beijing 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