{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:38:01Z","timestamp":1782603481251,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T00:00:00Z","timestamp":1495584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005367","name":"American Foundation for Surgery of the Hand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Although collagen\u2010rich deposits are the main component of neural scars, the patterns of their formation are ill defined. Essential to the biosynthesis of collagen fibrils are enzymes catalyzing posttranslational modifications and chaperones that control the formation of the collagen triple helix. Prolyl\u20104\u2010hydroxylase (P4H) and heat shock protein\u201047 (<jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>47) play a key role, and their production is upregulated during scar formation in human tissues. Alpha smooth muscle actin (\u03b1<jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content>) is also produced during fibrotic processes in myofibroblasts that participate in fibrotic response. In injured peripheral nerves, however, the distribution of cells that produce these markers is poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The goal of this study was to determine the distribution of the \u03b1<jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content>\u2010positive, <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>47\u2010positive, and the P4H\u2010positive cells to better understand the formation of collagen\u2010rich fibrotic tissue (FT) in response to peripheral nerve injury. To reach this goal, we employed a rabbit model of crush\u2010injury and partial\u2010transection injury of the sciatic nerves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our study demonstrated that \u03b1<jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content> is expressed in a relatively small number of cells seen in neural FT. In contrast, cells producing P4H and <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>47 are ubiquitously present in sites of injury of the sciatic nerves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We contemplate that these proteins may serve as valuable markers that define fibrotic activities in the injured peripheral nerves.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.659","type":"journal-article","created":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T16:20:23Z","timestamp":1495729223000},"source":"Crossref","is-referenced-by-count":9,"title":["Patterns of production of collagen\u2010rich deposits in peripheral nerves in response to injury: A pilot study in a rabbit model"],"prefix":"10.1002","volume":"7","author":[{"given":"Michael","family":"Rivlin","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Sidney Kimmel Medical College Thomas Jefferson University Philadelphia PA USA"},{"name":"Rothman Institute of Orthopaedics Thomas Jefferson University Hospital Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Miller","sequence":"additional","affiliation":[{"name":"Rothman Institute of Orthopaedics Thomas Jefferson University Hospital Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Tulipan","sequence":"additional","affiliation":[{"name":"Rothman Institute of Orthopaedics Thomas Jefferson University Hospital Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro K.","family":"Beredjiklian","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Sidney Kimmel Medical College Thomas Jefferson University Philadelphia PA USA"},{"name":"Rothman Institute of Orthopaedics Thomas Jefferson University Hospital Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark L.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Sidney Kimmel Medical College Thomas Jefferson University Philadelphia PA USA"},{"name":"Rothman Institute of Orthopaedics Thomas Jefferson University Hospital Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Fertala","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Sidney Kimmel Medical College Thomas Jefferson University Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Steplewski","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Sidney Kimmel Medical College Thomas Jefferson University Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Kostas","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Sidney Kimmel Medical College Thomas Jefferson University Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9153-1912","authenticated-orcid":false,"given":"Andrzej","family":"Fertala","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Sidney Kimmel Medical College Thomas Jefferson University Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.9.4.113"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000230519.39456.ea"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/foc.2004.16.5.2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-011-0874-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-239533"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1482-4"},{"key":"e_1_2_7_8_1","first-page":"593","article-title":"Schwann cell extracellular matrix molecules and their receptors","volume":"15","author":"Chernousov M. 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