{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:56:13Z","timestamp":1790110573189,"version":"4.0.1"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T00:00:00Z","timestamp":1489536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2017,4]]},"abstract":"Abstract<\/jats:title>\n \n Background and Purpose<\/jats:title>\n \n Although diffusion\u2010weighted imaging (\n DWI<\/jats:styled-content>\n ) is a very sensitive technique for the detection of small ischemic lesions in the human brain, in particular in the brainstem it may fail to demonstrate acute ischemic infarction. In this study, we sought to evaluate the value of additional thin\u2010section coronal\n DWI<\/jats:styled-content>\n for the detection of brainstem infarction.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In 155 consecutive patients (median age 69 [interquartile range,\n IQR<\/jats:styled-content>\n 57\u201378]\u00a0years, 95 [61.3%] males) with isolated brainstem infarction,\n MRI<\/jats:styled-content>\n findings were analyzed, with emphasis on ischemic lesions on standard axial (5\u00a0mm) and thin\u2010section coronal (3\u00a0mm)\n DWI<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n On\n DWI<\/jats:styled-content>\n , we identified ischemic lesions in the mesencephalon in 12 (7.7%), pons in 115 (74.2%), and medulla oblongata in 31 (20%) patients. In 3 (1.9%) cases\u2014all of these with medulla oblongata infarction\u2014the ischemic lesion was detected only on thin\u2010section coronal\n DWI<\/jats:styled-content>\n . Overall, in 35 (22.6%) patients the ischemic lesion was more easily identified on thin\u2010section coronal\n DWI<\/jats:styled-content>\n in comparison to standard axial\n DWI<\/jats:styled-content>\n . In these, the ischemic lesions were significantly smaller (0.06 [\n IQR<\/jats:styled-content>\n 0.05\u20130.11]\u00a0cm\n 3<\/jats:sup>\n vs. 0.25 [\n IQR<\/jats:styled-content>\n 0.13\u20130.47]\u00a0cm\n 3<\/jats:sup>\n ;\n p<\/jats:italic>\n \u00a0<\u00a0.001) in comparison to those patients whose ischemic lesion was more easily (6 [3.9%]) or at least similarly well identified (114 [73.5%]) on standard axial\n DWI<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Since thin\u2010section coronal\n DWI<\/jats:styled-content>\n may facilitate the diagnosis of brainstem infarction, we suggest its inclusion in standard stroke\n MRI<\/jats:styled-content>\n protocols.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/brb3.666","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T01:22:44Z","timestamp":1489540964000},"source":"Crossref","is-referenced-by-count":27,"title":["Combination of standard axial and thin\u2010section coronal diffusion\u2010weighted imaging facilitates the diagnosis of brainstem infarction"],"prefix":"10.1002","volume":"7","author":[{"given":"Philippe","family":"Felfeli","sequence":"first","affiliation":[{"name":"Department of Neuroradiology Universit\u00e4tsmedizin Mannheim University of Heidelberg Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Wenz","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Universit\u00e4tsmedizin Mannheim University of Heidelberg Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansour","family":"Al\u2010Zghloul","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Universit\u00e4tsmedizin Mannheim University of Heidelberg Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Groden","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Universit\u00e4tsmedizin Mannheim University of Heidelberg Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8679-0060","authenticated-orcid":false,"given":"Alex","family":"F\u00f6rster","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Universit\u00e4tsmedizin Mannheim University of Heidelberg Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1754-9485.12490"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2010.03.005"},{"key":"e_1_2_7_4_1","first-page":"1434","article-title":"False\u2010negative diffusion\u2010weighted MR findings in acute ischemic stroke","volume":"21","author":"Oppenheim C.","year":"2000","journal-title":"American Journal of Neuroradiology"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sult.2013.01.004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10278-004-1014-6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.48.108"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.497453"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.5.1125"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-002-0897-5"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/jscd.2000.0090070"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbrb3.666","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T19:16:55Z","timestamp":1696619815000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,15]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1002\/brb3.666"],"URL":"https:\/\/doi.org\/10.1002\/brb3.666","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,15]]},"article-number":"e00666"}}