{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:36:25Z","timestamp":1790710585600,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T00:00:00Z","timestamp":1494979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Changes in neural activity induce changes in functional magnetic resonance (<jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content>) blood oxygenation level dependent (<jats:styled-content style=\"fixed-case\">BOLD<\/jats:styled-content>) signal. Commonly, increases in <jats:styled-content style=\"fixed-case\">BOLD<\/jats:styled-content> signal are ascribed to cellular excitation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The relationship between electrical activity and <jats:styled-content style=\"fixed-case\">BOLD<\/jats:styled-content> signal in the human brain was probed on the basis of burst suppression <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>. This condition includes two distinct states of high and low electrical activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Resting\u2010state simultaneous <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BOLD<\/jats:styled-content> measurements were acquired during deep sevoflurane anesthesia with burst suppression <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content> in nineteen healthy volunteers. Afterwards, <jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content> volumes were assigned to one of the two states (burst or suppression) as defined by the <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the frontal, parietal and temporal lobes as well as in the basal ganglia, <jats:styled-content style=\"fixed-case\">BOLD<\/jats:styled-content> signal increased after burst onset in the <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content> and decreased after onset of <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content> suppression. In contrast, <jats:styled-content style=\"fixed-case\">BOLD<\/jats:styled-content> signal in the occipital lobe was anticorrelated to electrical activity. This finding was obtained consistently in a general linear model and in raw data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In human brains exhibiting burst suppression <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content> induced by sevoflurane, the positive correlation between <jats:styled-content style=\"fixed-case\">BOLD<\/jats:styled-content> signal and electrical brain activity could be confirmed in most gray matter. The exceptional behavior of the occipital lobe with an anticorrelation of <jats:styled-content style=\"fixed-case\">BOLD<\/jats:styled-content> signal and electrical activity might be due to specific neurovascular coupling mechanisms that are pronounced in the deeply anesthetized brain.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.679","type":"journal-article","created":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T04:13:00Z","timestamp":1495080780000},"source":"Crossref","is-referenced-by-count":25,"title":["Coherence of <scp>BOLD<\/scp> signal and electrical activity in the human brain during deep sevoflurane anesthesia"],"prefix":"10.1002","volume":"7","author":[{"given":"Daniel","family":"Golkowski","sequence":"first","affiliation":[{"name":"Department of Neurology Klinikum rechts der Isar der Technischen Universit\u00e4t M\u00fcnchen  M\u00fcnchen 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