{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:05:32Z","timestamp":1753862732871,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T00:00:00Z","timestamp":1493337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400946"],"award-info":[{"award-number":["81400946"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The risk of recurrent stroke is high in patients with intracranial atherosclerotic stenosis (<jats:styled-content style=\"fixed-case\">ICAS<\/jats:styled-content>). Statin use has been demonstrated to decrease the incidence of stroke by reducing atherosclerotic plaque burden. However, its effect on the hemodynamic situation and cerebral perfusion status has not yet been validated. With the use of computed tomography perfusion (<jats:styled-content style=\"fixed-case\">CTP<\/jats:styled-content>), we aim to evaluate the impact of Rosuvastatin on cerebral hemodynamic changes, as well as the downstream perfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Cerebral bood flow evaluation of intensive rosuvastatin therapy in patients with intracranial arterial atherosclerotic stenosis (<jats:styled-content style=\"fixed-case\">CEIRIS<\/jats:styled-content>) is a single\u2010center, prospective, randomized, parallel\u2010group, and open\u2010label trial, and it will include 50 participants as estimated. Patients with moderate to severe (50%\u201399%) <jats:styled-content style=\"fixed-case\">ICAS<\/jats:styled-content> are randomized 1:1 to 10\u00a0mg\/day or 20\u00a0mg\/day Rosuvastatin and followed every 13\u00a0weeks until 52\u00a0weeks. The primary outcome for the trial is the change in the relative regional cerebral blood flow evaluated by <jats:styled-content style=\"fixed-case\">CTP<\/jats:styled-content> after 52\u00a0weeks of Rosuvastatin treatment. The secondary outcomes are cerebral blood volume, change in the degree of stenosis of the target vessel and lipid parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">CEIRIS<\/jats:styled-content> trial about the effects of statin on the temporal hemodynamic progression of <jats:styled-content style=\"fixed-case\">ICAS<\/jats:styled-content> may extend our understanding of the basic pathophysiology and mechanisms of stroke in <jats:styled-content style=\"fixed-case\">ICAS<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.689","type":"journal-article","created":{"date-parts":[[2017,4,29]],"date-time":"2017-04-29T04:35:55Z","timestamp":1493440555000},"source":"Crossref","is-referenced-by-count":4,"title":["Cerebral blood flow evaluation of intensive rosuvastatin therapy in stroke\/transient ischemic attack patients with intracranial arterial atherosclerotic stenosis study: Rationale\u00a0and design"],"prefix":"10.1002","volume":"7","author":[{"given":"Xuting","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology School of Medicine The Second Affiliated Hospital of Zhejiang University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3577-4527","authenticated-orcid":false,"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology School of Medicine The Second Affiliated Hospital of Zhejiang University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology School of Medicine The Second Affiliated Hospital of Zhejiang University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhong","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Radiology School of Medicine The Second Affiliated Hospital of Zhejiang University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Neurology School of Medicine The Second Affiliated Hospital of Zhejiang University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000147965.52712.fa"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.594739"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2010.00528.x"},{"issue":"5","key":"e_1_2_6_5_1","first-page":"1012","article-title":"Intracranial vascular stenosis and occlusive disease: Evaluation with CT angiography, MR angiography, and digital subtraction angiography","volume":"26","author":"Bash S.","year":"2005","journal-title":"American Journal of Neuroradiology"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.1.87"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.55.11.1475"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.12.1344"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00170-3"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(13)62038\u20103"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.15.8880"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.122"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.578229"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.111.635755"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.3.457"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2564"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32834ec16b"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.7.1758"},{"issue":"4","key":"e_1_2_6_20_1","first-page":"643","article-title":"A standardized method for measuring intracranial arterial stenosis","volume":"21","author":"Samuels O. 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