{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T20:16:55Z","timestamp":1770322615738,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T00:00:00Z","timestamp":1491523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7142051"],"award-info":[{"award-number":["7142051"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Numerous types of infection were closely related to <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content>, mainly including <jats:italic>Campylobacter jejuni<\/jats:italic>, Cytomegalovirus, which may lead to the production of anti\u2010gangliosides antibodies (<jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content>)<jats:bold>.<\/jats:bold> Currently, although there are increased studies on the <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content> and a few studies of anti\u2010<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> antibodies in <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content>, the association between them remains poorly documented. Therefore, our research aims to analyze the correlation of anti\u2010<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> antibodies and <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 29 patients with <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> were enrolled in this study. The <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> antibodies were tested by the electrochemiluminescence immunoassay \u201c<jats:styled-content style=\"fixed-case\">ECLIA<\/jats:styled-content>\u201d (Roche Diagnostics GmbH). The serum gangliosides were determined by The <jats:styled-content style=\"fixed-case\">EUROLINE<\/jats:styled-content> test kit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 29 patients with <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content>, 9 (31%) were <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content>\u2010seropositive, in which 22 were <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>\u2010IgG positive in <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> at the same time, but all 29 samples were <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>\u2010IgM negative in both serum and <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>. In the <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content>\u2010positive group, the rate of both serum and <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> positive was 87.5% (7\/8), higher than 50% (7\/14) of the negative group, although no statistical significance was found. In addition, we found that there was a trend of higher ratio of men, a younger age onset, less frequent preceding infection, a higher level of <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> proteins, and less frequent cranial nerve deficits, although the data did not reach a statistical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In spite of no statistical significance association was found between serum <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>\u2010IgG in serum and <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>. However, we found that there was a trend of high positive rate of both serum and <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>\u2010IgG in <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content>\u2010positive than the negative group. So we should further expand the sample size to analyze the association between <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> or other neurotropic virus antibodies in various diseases, to observe whether they could be serological marker of these diseases (especially <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content>) or the underlying pathogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.690","type":"journal-article","created":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T12:18:42Z","timestamp":1491567522000},"source":"Crossref","is-referenced-by-count":5,"title":["Association of anti\u2010gangliosides antibodies and anti\u2010<scp>CMV<\/scp> antibodies in Guillain\u2013Barr\u00e9 syndrome"],"prefix":"10.1002","volume":"7","author":[{"given":"Lijuan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunqing","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunjiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xixiong","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases  Beijing China"},{"name":"Monogenic Disease Research Center for Neurological Disorder  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3946-3988","authenticated-orcid":false,"given":"Guojun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases  Beijing China"},{"name":"Monogenic Disease Research Center for Neurological Disorder  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(03)00149-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9430-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.121"},{"issue":"5","key":"e_1_2_7_5_1","first-page":"589","article-title":"Antiganglioside autoantibody profiles in Guillain\u2010Barre syndrome","volume":"60","author":"Caudie C.","year":"2002","journal-title":"Annales de Biologie Clinique"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww078"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.3730"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.07.014"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25266"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(97)00166-5"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355830"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(96)00059-8"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0775-0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199704)20:4<446::AID-MUS7>3.0.CO;2-A"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.4.1110"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.62.6.641"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(99)00040-5"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70130-8"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(82)83012-7"},{"key":"e_1_2_7_20_1","first-page":"182","article-title":"Anti\u2010ganglioside antibodies in peripheral neuropathy","volume":"29","author":"McCombe P. 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