{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T10:24:29Z","timestamp":1769941469743,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,14]],"date-time":"2017-04-14T00:00:00Z","timestamp":1492128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2017,6]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Sexual dysfunction (SD<\/jats:styled-content>) is one of the common symptoms of multiple sclerosis (MS<\/jats:styled-content>) and is often underdiagnosed, especially in women. Relapsing\u2010remitting multiple sclerosis (RRMS<\/jats:styled-content>) is the most widespread form of the disease, but the data on SD<\/jats:styled-content> occurrence in this particular group of patients is limited. The aim of the study was to analyze the associations between demographic factors, symptoms and signs of MS<\/jats:styled-content>, psychiatric comorbidities and SD<\/jats:styled-content> in female patients with RRMS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Material & Methods<\/jats:title>A subgroup of 86 sexually active women with RRMS<\/jats:styled-content> out of 218 total MS<\/jats:styled-content> respondents was analyzed. Exclusion criteria included active relapse, EDSS<\/jats:styled-content> score equal or higher than 6.5, and current pregnancy. All patients completed questionnaires including demographic data, questions about symptoms and signs of MS<\/jats:styled-content>, Female Sexual Function Index (FSFI<\/jats:styled-content>) for sexual performance, Patient Health Questionnaire 9 (PHQ<\/jats:styled-content>\u20109) for depression, and Fatigue Severity Scale (FSS<\/jats:styled-content>) for fatigue evaluation.<\/jats:p><\/jats:sec>Results<\/jats:title>According to FSFI<\/jats:styled-content>, SD<\/jats:styled-content> occurred in 21 (27.27%) of the respondents. SD<\/jats:styled-content> occurrence was associated with depression (p<\/jats:italic>\u00a0<\u00a0.05) and speech disturbances (p<\/jats:italic>\u00a0<\u00a0.04). A negative effect on sexual performance was associated with depression intensity (p<\/jats:italic>\u00a0<\u00a0.003), fatigue intensity (p<\/jats:italic>\u00a0<\u00a0.05), more advanced age at diagnosis (p<\/jats:italic>\u00a0<\u00a0.02), lower education level (p<\/jats:italic>\u00a0<\u00a0.05), and smaller area of residence (p<\/jats:italic>\u00a0<\u00a0.002).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>SD<\/jats:styled-content> in women with RRMS<\/jats:styled-content> is mostly associated with psychosocial parameters. Patients who are more depressed, presenting speech problems, less educated, and from smaller towns, should be considered high\u2010risk for sexual dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.699","type":"journal-article","created":{"date-parts":[[2017,4,15]],"date-time":"2017-04-15T04:12:48Z","timestamp":1492229568000},"source":"Crossref","is-referenced-by-count":38,"title":["Sexual dysfunction in female patients with relapsing\u2010remitting multiple sclerosis"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9873-8833","authenticated-orcid":false,"given":"Pawel","family":"Bartnik","sequence":"first","affiliation":[{"name":"Students\u2019 Research Group at the 1st Department of Obstetrics and Gynecology Medical University of Warsaw Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Wielgo\u015b","sequence":"additional","affiliation":[{"name":"Students\u2019 Research Group at the 1st Department of Obstetrics and Gynecology Medical University of Warsaw Warsaw Poland"},{"name":"Department of Experimental and Clinical Physiology Medical University of Warsaw Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Kacperczyk","sequence":"additional","affiliation":[{"name":"Students\u2019 Research Group at the 1st Department of Obstetrics and Gynecology Medical University of Warsaw Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Pisarz","sequence":"additional","affiliation":[{"name":"Students\u2019 Research Group at the Department of Neurology Medical University of Warsaw Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwona","family":"Szymusik","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynecology Medical University of Warsaw Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Podlecka\u2010Pi\u0119towska","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Warsaw Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata","family":"Zakrzewska\u2010Pniewska","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Warsaw Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miroslaw","family":"Wielgo\u015b","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynecology Medical University of Warsaw Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458513489758"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/57.1.81"},{"key":"e_1_2_8_4_1","first-page":"255","article-title":"Sexual dysfunction in relapsing\u2010remitting multiple sclerosis: Magnetic resonance imaging, clinical, and psychological correlates","volume":"21","author":"Barak Y.","year":"1996","journal-title":"The Journal of Psychiatry & Neuroscience"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.08.019"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.09.023"},{"issue":"2","key":"e_1_2_8_7_1","first-page":"16","article-title":"Natural history of multiple sclerosis","volume":"71","author":"Ebers G. 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