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The complicated etiology of PD is thought to involve a summation of aging, genetic predisposition, and environmental variables. However, the \u03b1\u2010synuclein protein plays a significant role in the disease's pathophysiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      The UAS\u2010\u03b1\u2010Syn and Ddc\u2010Gal4 strains were crossed to produce offspring referred to as PD flies. The entire population of flies was divided into five groups, each having about 100 flies and five replicates. The control group (w\n                      <jats:sup>1118<\/jats:sup>\n                      ) and the PD group not receiving treatment were exposed to lauric acid (LA)\/levodopa (LD)\u2010free diet, while the PD groups that received treatments were fed with either a 250\u00a0mg\/kg LA diet, a 250\u00a0mg\/kg LD diet, or a combination of the two for 21 days. Longevity, geotaxis, and olfactory assays were performed in addition to other biochemical tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      As a result of the overexpression of \u03b1\u2010synuclein, the locomotive capacity, lifespan, and antioxidant status were all significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05)\u00a0reduced, and the apoptotic and neuroinflammatory activities were increased. Nevertheless, the majority of the treated flies improved significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      LA, whether combined with LD or not, elicited a significant response in \u03b1\u2010synuclein\/dopa decarboxylase genetically modified\n                      <jats:italic>Drosophila melanogaster<\/jats:italic>\n                      Parkinsonism models.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.70001","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T02:41:28Z","timestamp":1725849688000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Lauric acid with or without 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